계명대학교 의학도서관 Repository

The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort

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Author(s)
Jisuk BaeDong Hoon ShinByung-Yeol ChunBo Youl ChoiMi Kyung KimMin-Ho ShinYoung-Hoon LeePil Sook ParkSeong-Kyu Kim
Keimyung Author(s)
Shin, Dong Hoon
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
Joint Bone Spine
Issued Date
2014
Volume
81
Issue
6
Keyword
Vitamin CUric acidHyperuricemia
Abstract
Objective: The aim of this study was to determine the association between vitamin C intake and risk ofhyperuricemia or serum uric acid levels in male and female subjects in the Korean Multi-Rural Commu-nities Prospective Cohort.Methods: This cross-sectional analysis was conducted in 9400 subjects enrolled in the Korean Multi-RuralCommunities Cohort Study. The risk of hyperuricemia was assessed in five quintiles (Q1 to Q5) accordingto dietary and total vitamin C intake using multivariate-adjusted logistic regression models. Relationshipsbetween serum uric acid levels and vitamin C intake were evaluated using linear regression analysis afteradjustment for covariates. Information about dietary components was collected using validated foodfrequency questionnaires.Results: Dietary vitamin C intake, but not total vitamin C intake, was significantly different betweenhyperuricemic and non-hyperuricemic subjects in males (P = 0.01) and females (P = 0.02). The risk ofhyperuricemia decreased with increased dietary vitamin C intake in male and female subjects after mul-tivariate adjustment (P for trend = 0.002 in males and P for trend = 0.02 in females). An effect of totalvitamin C intake on hyperuricemia risk was identified in females (P for trend = 0.04), but not males (Pfor trend = 0.06). Serum uric acid level was linearly associated with total vitamin C intake in females( = −0.0001, P = 0.01), but not with dietary vitamin C intake in either gender.Conclusion: This study showed that vitamin C intake might be in part responsible for hyperuricemia orserum uric acid level in the Korean Multi-Rural Communities Cohort.
Keimyung Author(s)(Kor)
신동훈
Publisher
School of Medicine
Citation
Jisuk Bae et al. (2014). The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort. Joint Bone Spine, 81(6), 513–519. doi: 10.1016/j.jbspin.2014.05.007
Type
Article
ISSN
1297-319X
Source
https://www.sciencedirect.com/science/article/pii/S1297319X1400150X?via%3Dihub
DOI
10.1016/j.jbspin.2014.05.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33923
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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