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Stressful events, stress perception and treatment outcomes in patients with depressive disorders: The CRESCEND study

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Author(s)
Jae-Min KimSung-Wan KimRobert StewartHee-Ju KangIl-Seon ShinSung-Won JungMin-Soo LeeHyeon-Woo YimTae-Youn Jun
Keimyung Author(s)
Jung, Sung Won
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Journal of Affective Disorders
Issued Date
2011
Volume
133
Issue
3
Keyword
DepressionStressTreatment outcomeKoreaAntidepressant
Abstract
Background: Investigations of associations between stressful events and depression treatment
outcomes have led to conflicting findings. In a prospective naturalistic study of depression
treatment we sought to investigate perceived stress as a predictor of 12-week antidepressant
treatment outcome.
Methods: A nationwide sample of 580 people with depressive disorders was recruited from 18
hospitals in Korea. Number of stressful events in the last 12 months and subjective perception
of stress were ascertained, and were dichotomized by median values. Participants commenced
on antidepressant treatment were re-evaluated at 1, 2, 4, 8, and 12 weeks later. Assessment
scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and
functioning (SOFAS) were administered at baseline and at every follow-up visit. Covariates
included pre-treatment socio-demographic and clinical characteristics, and treatment-related
characteristics.
Results: Higher baseline perceived stress was significantly associated with worse 12-week
antidepressant treatment outcomes in terms of depression, anxiety, and global severity after
adjustment for all covariates. However, baseline number of stressful events was not associated
with any treatment outcomes.
Limitations: The study was observational, and the treatment modality was naturalistic.
Conclusions: Depressive patients with higher level of perceived stress at the time of
commencing treatment had less favorable outcomes after antidepressant treatment. This
may represent a group requiring more specific assessment and more intensive management in
order to improve treatment response.
Keimyung Author(s)(Kor)
정성원
Publisher
School of Medicine
Citation
Jae-Min Kim et al. (2011). Stressful events, stress perception and treatment outcomes in patients with depressive disorders: The CRESCEND study. Journal of Affective Disorders, 133(3), 528–536. doi: 10.1016/j.jad.2011.05.002
Type
Article
ISSN
0165-0327
Source
https://www.sciencedirect.com/science/article/pii/S0165032711002400?via%3Dihub
DOI
10.1016/j.jad.2011.05.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33936
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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