계명대학교 의학도서관 Repository

Persistence and resolution of suicidal ideation during treatment of depression in patients with significant suicidality at the beginning of treatment: The CRESCEND study

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Author(s)
Ho-Jun SeoYoung-Eun JungSeunghee JeongJung-Bum KimMin-Soo LeeJae-Min KimHyeon Woo YimTae-Youn Jun
Keimyung Author(s)
Kim, Jung Bum
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Journal of Affective Disorders
Issued Date
2014
Volume
155
Keyword
DepressionSuicide ideationPredictive factorPersistent suicidalityResolved suicidality
Abstract
Background.

The appropriate length of time for patients who visit clinics with significant suicidal ideation to be closely monitored is a critical issue for clinicians. We evaluated the course of suicidal ideation and associated factors for persistent suicidality in patients who entered treatment for depression with significant suicidal ideation.


Methods.

A total of 565 patients who had both moderate to severe depression (Hamilton Depression Rating Scale (HAMD) score ≥14) and significant suicidal ideation (Beck Scale for Suicide Ideation (SSI-B) score ≥6) were recruited from 18 hospitals in South Korea. Participants were assessed using the SSI-B, HAMD, Hamilton Anxiety Rating Scale, and Clinical Global Impression Scale-severity during a 12-week naturalistic treatment with antidepressant intervention. Participants were classified into resolved suicidality or persistent suicidality groups according to whether their suicidal ideation improved to SSI-B scores <6 and were sustained for 12 weeks.


Results.

During the 12-week treatment, 206 (36.4%) patients were classified in the resolved suicidality group. Persistent suicidality was associated with intervention with SSRIs, higher SSI-B baseline score, and no HAMD or HAMA remission. The proportions of participants who had persistent suicidal ideation even with HAMD remission or response were 0.25 and 0.34, respectively.


Limitations.

This study was observational, and the treatment modality was naturalistic.


Conclusions.

A considerable number of patients had persistent suicidal ideation despite 12 weeks of antidepressant treatment. Close monitoring for suicidal ideation may be needed beyond the initial weeks of treatment and even after a response to antidepressants is observed.
Keimyung Author(s)(Kor)
김정범
Publisher
School of Medicine
Citation
Ho-Jun Seo et al. (2014). Persistence and resolution of suicidal ideation during treatment of depression in patients with significant suicidality at the beginning of treatment: The CRESCEND study. Journal of Affective Disorders, 155, 208–215. doi: 10.1016/j.jad.2013.11.002
Type
Article
ISSN
0165-0327
Source
https://www.sciencedirect.com/science/article/pii/S0165032713007969?via%3Dihub
DOI
10.1016/j.jad.2013.11.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33939
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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