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Microbial Profile of the Stomach: Comparison between Normal Mucosa and Cancer Tissue in the Same Patient

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Author(s)
Incheol SeoBijay Kumar JhaSeong-Il SuhMin-Ho SuhWon-Ki Baek
Keimyung Author(s)
Suh, Seong IlSuh, Min HoBaek, Won Ki
Department
Dept. of Microbiology (미생물학)
Journal Title
Journal of Bacteriology and Virology
Issued Date
2014
Volume
44
Issue
2
Keyword
Gastric cancerHelicobacter pyloriMicrobiome
Abstract
predicted that gastric cancer will remain an important cause of death at least during the next half century because of the
increasing number of new cases in an aging population. However, little has been revealed about the role of gastric
microbes and their reaction to gastric cancer. In this study, we identified differences in the microbial communities between
gastric cancer and normal gastric mucosa by comparing the microbiomes of tissues from the same patients. The clustering
analysis results showed different bacterial communities between normal gastric mucosa and gastric cancer. A comparison
of bacterial communities at the species level revealed that Helicobacter pylori was significantly reduced in cancer tissue
compared to that in normal gastric mucosa in the same patient. A comparison at the genus level showed that
Propionibacterium spp., Staphylococcus spp., and Corynebacterium spp. had significantly reduced populations in cancer
tissue, whereas Clostridium spp. and Prevotella spp. had significantly increased populations in cancer tissue.
Keimyung Author(s)(Kor)
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Publisher
School of Medicine
Citation
Incheol Seo et al. (2014). Microbial Profile of the Stomach: Comparison between Normal Mucosa and Cancer Tissue in the Same Patient. Journal of Bacteriology and Virology, 44(2), 162–169. doi: 10.4167/jbv.2014.44.2.162
Type
Article
ISSN
1598-2467
DOI
10.4167/jbv.2014.44.2.162
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33948
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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