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Catechol-O-Methyltransferase Activity in Cholestatic Rat's Liver Induced by Bile Duct Ligation

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Author(s)
Kyo-Cheol Mun
Keimyung Author(s)
Mun, Kyo Cheol
Department
Dept. of Biochemistry (생화학)
Journal Title
Journal of Biochemistry & Molecular Biology
Issued Date
1996
Volume
29
Issue
2
Keyword
catechol-O-methyltransferasecholestasismonoamine oxidase
Abstract
To investigate the cause of increased plasma catecholamine levels in liver disease, catechol-O-methyltransferase (COMT), which provides a major route of catabolism for circulating catecholamines, was studied under the cholestasis induced by mechanical biliary obstruction in rats. Monoamine oxidase (MAO) activity and the and values for both enzymes were also measured. Cytosolic, microsomal, and mitochondrial COMT activities in the cholestatic liver were significantly decreased throughout the experiment. Microsomal, and mitochondrial MAO activity in the cholestatic liver were also significantly decreased. Vmax values of COMT and MAO were lower. Serum COMT and MAO activities were detected after CBD ligation. These results indicate that plasma catecholamine levels are increased in liver disease due to decreased hepatic degradation of catecholamines by decreased activities of COMT and MAO. The decreased activity of these enzymes is caused by decreased biosynthesis and by flowage into the blood from the damaged hepatocyte.
Keimyung Author(s)(Kor)
문교철
Publisher
School of Medicine
Citation
Kyo-Cheol Mun. (1996). Catechol-O-Methyltransferase Activity in Cholestatic Rat’s Liver Induced by Bile Duct Ligation. Journal of Biochemistry & Molecular Biology, 29(2), 142–145.
Type
Article
ISSN
1225-8687
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33949
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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