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Malondialdehyde Levels in Middle Ear Fluid from Patients of Otitis Media with Effusion

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Author(s)
Kyo-Cheol MunDeok-Jun Kim
Keimyung Author(s)
Mun, Kyo CheolKim, Deok Jun
Department
Dept. of Biochemistry (생화학)
Dept. of Otorhinolaryngology (이비인후과학)
Journal Title
Journal of Biochemistry & Molecular Biology
Issued Date
1999
Volume
32
Issue
1
Keyword
MalondialdehydeOtitis media with effusionOxygen free radiclas
Abstract
Otitis media with effusion (OME) is an inflammatory disease of the middle ear cleft. Oxygen free radicals have been implicated in a variety of inflammatory disorders. Oxygen free radicals may also be involved in the pathogenesis of OME. To evaluate the involvement of oxygen free radicals in the pathogenesis of OME, the level of malondialdehyde, which gives an index of lipid peroxidation by oxygen free radicals, was measured by the reaction with thiobarbituric acid. Malondialdehyde level in the middle ear fluid from the OME group was higher than that in the normal control group. Malondialdehyde level in the middle ear fluid from a mucoid subgroup was higher than that in the serous subgroup. Malondialdehyde levels in the middle ear fluid from the serous subgroup was significantly correlated with symptom duration. The Pearson correlation coefficient between malondialdehyde levels in the middle ear fluid from the serous subgroup and symptom duration was 0.842 (P<0.05). These results indicate that lipid peroxidation by oxygen free radicals may be involved in the pathogenesis of human OME.
Keimyung Author(s)(Kor)
문교철
김덕준
Publisher
School of Medicine
Citation
Kyo-Cheol Mun and Deok-Jun Kim. (1999). Malondialdehyde Levels in Middle Ear Fluid from Patients of Otitis Media with Effusion. Journal of Biochemistry & Molecular Biology, 32(1), 25–27.
Type
Article
ISSN
1225-8687
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33951
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
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