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Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder

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Author(s)
C. H. ChoY. M. LhoE. HaI. HwangK. S. SongB. W. MinK. C. BaeD. H. Kim
Keimyung Author(s)
Cho, Chul HyunSong, Kwang SoonMin, Byung WooBae, Ki CheorHa, Eun YoungHwang, Il SeonKim, Du Hwan
Department
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Biochemistry (생화학)
Dept. of Pathology (병리학)
Dept. of Rehabilitation Medicine (재활의학)
Journal Title
Bone & Joint Journal
Issued Date
2015
Volume
97-B
Issue
6
Keyword
Frozen shoulderJoint capsuleAcid-Sensing Ion Channel
Abstract
The purpose of this study was to evaluate the expression of acid-sensing ion channels (ASICs) in the capsule and synovial fluid of patients with frozen shoulder. Capsular tissue and synovial fluid were obtained from 18 patients with idiopathic frozen shoulder (FS group) and 18 patients with instability of the shoulder (control group). The expressions of ASIC1, ASIC2, and ASIC3 in the capsule were determined using the reverse transcriptase-polymerase chain reaction, immunoblot analysis, and immunohistochemistry (IHC). The concentrations in synovial fluid were evaluated using an enzyme-linked immunosorbent assay.

The mRNA expression of ASIC1, ASIC2 and ASIC3 in the capsule were significantly increased in the FS group compared with the control group. The protein levels of these three ASICs were also increased. The increased expressions were confirmed by IHC. Of the ASICs, ASIC3 showed the greatest increase in both mRNA and levels of expression compared with the control group. The levels of ASIC1 and ASIC3 in synovial fluid were significantly increased in the FS group.

This study suggests that ASICs may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder.
Keimyung Author(s)(Kor)
조철현
송광순
민병우
배기철
하은영
황일선
김두환
Publisher
School of Medicine
Citation
C. H. Cho et al. (2015). Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder. Bone & Joint Journal, 97-B(6), 824–829. doi: 10.1302/0301-620X.97B6.35254
Type
Article
ISSN
2049-4394
Source
https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.97B6.35254
DOI
10.1302/0301-620X.97B6.35254
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33954
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
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