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Effect Modification of Hormonal Therapy by p53 Status in Invasive Breast Cancer

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Author(s)
Sei Hyun AhnHwa Jung KimWonshik HanJihyoung ChoGyungyub GongKyung Hae JungSung-Bae KimByung Ho SonJong Won Lee
Keimyung Author(s)
Cho, Ji Hyoung
Department
Dept. of Surgery (외과학)
Journal Title
Journal of Breast Cancer
Issued Date
2013
Volume
16
Issue
4
Keyword
Breast neoplasmsDrug resistanceTumor suppressor protein p53
Abstract
Purpose:
We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status.


Methods:

Immunohistochemical data for p53, estrogen receptor, progesterone receptor, and HER2 expression from a total of 15,598 patients were retrospectively retrieved from the web-based database of the Korean Breast Cancer Society. Overall survival (OS) and breast cancer-specific survival (BCSS) were calculated and compared using the Kaplan-Meier method and log-rank test, respectively. Multivariate analyses were performed using a stratified Cox proportional hazard regression model. A model evaluating interactions between p53 expression and both hormonal therapy and chemotherapy was used to determine the treatment benefit from both modalities.


Results:

The prognostic value of p53 for OS and BCSS was most significant in the HR+/HER2- subgroup, with hazard ratios of 1.44 (95% confidence interval [CI], 1.08-1.93) and 1.47 (95% CI, 1.09-1.99), respectively. The p53 overexpression hazard ratios were of borderline significance for the HR+/HER2+ subgroup and were not significant for the HR-/HER2+ and HR-/HER2- subgroups. The model with interaction terms revealed that hormonal therapy significantly interacts with p53 status (p=0.002 and p=0.007 for OS and BCSS, respectively), suggesting an insignificant prognostic value for p53 status (p=0.268 and p=0.296 for OS and BCSS, respectively). An interaction between chemotherapy and p53 status was not found in this model.


Conclusion:

p53 overexpression has independent prognostic value, particularly in cases of HR+/HER2- invasive breast cancer, which may be due to effect modification of hormonal therapy dependent on p53 status.
Keimyung Author(s)(Kor)
조지형
Publisher
School of Medicine
Citation
Sei Hyun Ahn et al. (2013). Effect Modification of Hormonal Therapy by p53 Status in Invasive Breast Cancer. Journal of Breast Cancer, 16(4), 386–394. doi: 10.4048/jbc.2013.16.4.386
Type
Article
ISSN
1738-6756
DOI
10.4048/jbc.2013.16.4.386
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33957
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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