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Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats

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Author(s)
Young R KimIn J HuangSeong-Ryong LeeEmiri TejimaJoseph B MandevilleMaurits PA van MeerGeorge DaiYong W ChoiRick M DijkhuizenEng H LoBruce R Rosen
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Journal Title
Journal of Cerebral Blood Flow and Metabolism
Issued Date
2005
Volume
25
Issue
7
Keyword
BOLDCBVfMRIMCAOstrokethalamus
Abstract
Brain responses to external stimuli after permanent and transient ischemic insults have been
documented using cerebral blood volume weighted (CBVw) functional magnetic resonance imaging
(fMRI) in correlation with tissue damage and neurological recovery. Here, we extend our previous
studies of stroke recovery in rat models of focal cerebral ischemia by comparing blood oxygen leveldependent
(BOLD) and cerebral blood volume (CBV) changes. Responses to forepaw stimulation
were measured in normal rats (n¼5) and stroke rats subjected to 2 h of middle cerebral artery
occlusion (n¼6). Functional magnetic resonance imaging was performed 2 weeks after stroke to
evaluate the recovery process. After stroke, animals showed variable degrees of fMRI activation in
ipsilesional cortex, the extent of which did not correlate with structural damages as measured using
apparent diffusion coefficient, fractional anisotropy, blood volume, and vessel size index. While the
contralesional cortex showed good overlap between BOLD and CBV-activated regions, the
ipsilesional cortex showed low covariance between significantly activated voxels by BOLD and
CBVw techniques. In particular, the relative activation during contralateral stimuli in the ipsilesional
somatosensory cortex was significantly higher for CBVw responses than BOLD, which might be due
to stroke-related alterations in fMRI hemodynamic coupling. Aberrant subcortical activations were
also observed.When unaffected forelimbs were stimulated, strong bilateral responses were observed.
However, little thalamic responses accompanied stimulation of affected forelimbs despite significant
activation in the ipsilesional somatosensory cortex. These results suggest that stroke affects not only
local hemodynamics and coupling but also other factors including neural connectivity.
Keimyung Author(s)(Kor)
이성용
Publisher
School of Medicine
Citation
Young R Kim et al. (2005). Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats. Journal of Cerebral Blood Flow and Metabolism, 25(7), 820–829. doi: 10.1038/sj.jcbfm.9600084
Type
Article
ISSN
0271-678X
Source
http://journals.sagepub.com.proxy.dsmc.or.kr/doi/abs/10.1038/sj.jcbfm.9600084?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1038/sj.jcbfm.9600084
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33974
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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