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Positive Association of Obesity with Single Nucleotide Polymorphisms of Syndecan 3 in the Korean Population

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Author(s)
Eunyoung HaMi-Ja KimBong-Keun ChoiJung-Jae RhoDong-Jae OhTae-Hoon RhoKyu-Hyun KimHee Jae LeeDong-Hoon ShinSung Vin YimHyung Hwan BaikJoo-Ho ChungJong Woo Kim
Keimyung Author(s)
Shin, Dong HoonHa, Eun Young
Department
Dept. of Biochemistry (생화학)
Dept. of Preventive Medicine (예방의학)
Institute for Medical Science (의과학연구소)
Journal Title
Journal of Clinical Endocrinology and Metabolism
Issued Date
2006
Volume
91
Issue
12
Abstract
Context: Very recently the unforeseen role of syndecan 3 (SDC3), a family of membrane-bound heparin sulfate proteoglycans, in the regulation of energy balance has been discovered in the Sdc3 null female mice.

Objective: The objective of the study was to test the hypothesis that single nucleotide polymorphisms (SNPs) in SDC3 are associated with obesity in the Korean population.

Design/Setting/Subjects: We conducted a population-based cohort study consisting of 229 control and 245 study subjects and a second independent study consisting of 192 control and 115 study subjects.

Main Outcome Measurement: Body mass index (BMI) was measured.

Results: First, Sdc3 mRNA expression in the brain of ob/ob mice was profoundly increased, compared with control mice. Next, all three nonsynonymous SNPs [T271I (rs2282440, C>T), D245N (rs4949184, C>T), and V150I (rs2491132, C>T)] in the SDC3 gene in control female subjects (BMI < 23, n = 229) and obese female subjects (BMI > 30, n = 245) were genotyped. We demonstrated the presence of clear ethnic differences in three nonsynonymous SDC3 SNPs among African-Americans, Chinese, Europeans, and Koreans. Of three SNPs in SDC3, rs4949184 was not associated with obesity and the other two SNPs (rs2282440 and rs2491132) were strongly associated with obesity (P < 0.0001), and the results were confirmed in the second independent study group. Haplotype analysis also revealed strong association with obesity (χ2 = 76.92, P < 0.000001).

Conclusions: There are ethnic differences in the SDC3 polymorphisms, and the polymorphisms are strongly associated with obesity.
Keimyung Author(s)(Kor)
신동훈
하은영
Publisher
School of Medicine
Citation
Eunyoung Ha et al. (2006). Positive Association of Obesity with Single Nucleotide Polymorphisms of Syndecan 3 in the Korean Population. Journal of Clinical Endocrinology and Metabolism, 91(12), 5095–5099. doi: 10.1210/jc.2005-2086
Type
Article
ISSN
0021-972X
DOI
10.1210/jc.2005-2086
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33977
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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