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Predictive Factors of Impaired Quality of Life in Korean Patients With Inactive Inflammatory Bowel Disease Association With Functional Gastrointestinal Disorders and Mood Disorders

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Author(s)
Eun S. KimKwang B. ChoKyung S. ParkByung I. JangKyeong O. KimSeong W. JeonMin K. JungEun Y. KimChang H. YangDaegukyungbook Gastrointestinal Study Group (DGSG)
Keimyung Author(s)
Kim, Eun SooCho, Kwang BumPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Clinical Gastroenterology
Issued Date
2013
Volume
47
Issue
4
Keyword
inflammatory bowel diseasefunctional gastrointestinal disordermood disorderquality of life
Abstract
Background and Aim: Inflammatory bowel disease is a chronic and relapsing inflammatory disorder of the intestine and has a great effect on patients’ health-related quality of life (HRQOL). Some patients in remission are known to show functional gastrointestinal disorders (FGIDs) and mood disorders (MDs), which may also negatively impact HRQOL. The aim of this study was to evaluate predictors of impaired HRQOL in inactive inflammatory bowel disease (IBD) patients.

Methods: Patients presenting a long-standing remission during the previous year completed questionnaires of EuroQol, Rome III criteria for FGID, and Hospital Anxiety and Depression Survey. Demographic data including age, sex, employment status, education, smoking, and location of residence were also collected.

Results: Among the 513 patients with IBD, 226 (Crohn’s disease 107 and ulcerative colitis 119, age 39.01±15.63, male 141) defined in remission were enrolled. Overall, 147 (65.0%) had at least 1 FGID with irritable bowel syndrome being the most common disorder (36.3%). Anxiety and depression were identified in 27.4% and 33.6%, respectively. Participants with FGID or MD had a significantly lower HRQOL status than those without disorders (P<0.01). Among various demographic and clinical variables, aged 40 or older [odds ratio (OR), 2.342; 95% confidence interval (CI), 1.195-4.590; P=0.01], irritable bowel syndrome (OR, 3.932; 95% CI, 1.937-7.982; P<0.01), and anxiety (OR, 2.423; 95% CI, 1.067-5.502; P=0.03) were significant independent predictors of impaired HRQOL in inactive IBD patients.

Conclusions: FGID and MD are common in Korean quiescent IBD patients. Appropriate management should be administered according to age of patients and presence of concomitant FGID and MD to improve patients’ HRQOL.
Keimyung Author(s)(Kor)
김은수
조광범
박경식
Publisher
School of Medicine
Citation
Eun S. Kim et al. (2013). Predictive Factors of Impaired Quality of Life in Korean Patients With Inactive Inflammatory Bowel Disease Association With Functional Gastrointestinal Disorders and Mood Disorders. Journal of Clinical Gastroenterology, 47(4), e38–e44. doi: 10.1097/MCG.0b013e318266fff5
Type
Article
ISSN
0192-0790
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=23090047
DOI
10.1097/MCG.0b013e318266fff5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33979
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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