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Suicidality and Its Risk Factors in Korean People with Epilepsy: A MEPSY Study

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Author(s)
Jong-Geun SeoJang-Joon LeeYong Won ChoSe-Jin LeeJi-Eun KimHye-Jin MoonSung-Pa Park
Keimyung Author(s)
Cho, Yong WonMoon, Hye Jin
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Neurology
Issued Date
2015
Volume
11
Issue
1
Keyword
suicideepilepsydepressionanxietyadverse effectrisk factor
Abstract
Background and Purpose:

People with epilepsy (PWE) are more likely to experience suicidality, with suicidal ideation and attempts, than people without epilepsy (PWoE). The aims of the present study were to determine 1) the characteristics of suicidality in Korean PWE, 2) whether PWE with suicidality receive psychiatric intervention, and 3) the risk factors for suicidality.


Methods:

Patients who consecutively visited epilepsy clinics at secondary- and tertiary-care hospitals were recruited (n=684), along with age- and sex-matched PWoE (n=229). The presence of current major depressive disorder (MDD), generalized anxiety disorder (GAD), and/or suicidality was established using the Mini International Neuropsychiatric Interview-Plus Version 5.0.0. The Korean version of the Liverpool Adverse Events Profile (K-LAEP) was applied to detect adverse effects of antiepileptic drugs (AEDs).


Results:

Suicidality was present in 208 (30.4%) of the 684 PWE. The rate of suicidality was 4.6 times higher among PWE than PWoE, and 108 (15.7%) PWE had suicidal ideation and had attempted suicide. Among those who had attempted suicide, 40.7% had made at least two attempts. The most common method of suicide attempt was drug overdose (34.9%). Unfortunately, of the 208 PWE with suicidality, 136 (65.4%) did not receive psychiatric intervention. The risk factors for suicidality were MDD [odds ratio (OR)=6.448, 95% confidence interval (CI)=3.739-11.120, p<0.001], GAD (OR=3.561, 95% CI=1.966-6.452, p<0.001), item scores of 3 or 4 on the K-LAEP (OR=2.688, 95% CI=1.647-4.387, p<0.001), and a history of febrile convulsion (OR= 2.188, 95% CI=1.318-3.632, p=0.002).


Conclusions:

Suicidality is more prevalent in PWE than in PWoE. Clinicians should monitor psychiatric disorders and the adverse effects of AEDs in PWE in an attempt to reduce the incidence of suicidal ideation or suicide attempts in this patient population.
Keimyung Author(s)(Kor)
조용원
문혜진
Publisher
School of Medicine
Citation
Jong-Geun Seo et al. (2015). Suicidality and Its Risk Factors in Korean People with Epilepsy: A MEPSY Study. Journal of Clinical Neurology, 11(1), 32–41. doi: 10.3988/jcn.2015.11.1.32
Type
Article
ISSN
1738-6586
DOI
10.3988/jcn.2015.11.1.32
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33986
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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