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T2 Relaxometry Using 3.0-Tesla Magnetic Resonance Imaging of the Brain in Early- and Late-Onset Restless Legs Syndrome

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Author(s)
Hye-Jin MoonYongmin ChangYeong Seon LeeHee Jin SongHyuk Won ChangJeonghun KuYong Won Cho
Keimyung Author(s)
Moon, Hye JinCho, Yong WonChang, Hyuk WonKu, Jeong Hun
Department
Dept. of Neurology (신경과학)
Dept. of Radiology (영상의학)
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Journal of Clinical Neurology
Issued Date
2014
Volume
10
Issue
3
Keyword
restless legs syndromeT2 relaxometryred nucleussubstantia nigrairon
Abstract
Background and Purpose:

Previous T2 relaxometry studies have provided evidence for regional brain iron deficiency in patients with restless legs syndrome (RLS). Measurement of the iron content in several brain regions, and in particular the substantia nigra (SN), in early- and late-onset RLS patients using T2 relaxometry have yielded inconsistent results. In this study the regional iron content was assessed in patients with early- and late-onset RLS using magnetic resonance imaging (MRI), and compared the results with those in controls.


Methods:

Thirty-seven patients with idiopathic RLS (20 with early onset and 17 with late onset) and 40 control subjects were studied using a 3.0-tesla MRI with a gradient-echo sampling of free induction decay and echo pulse sequence. The regions of interest in the brain were measured independently by two trained analysts using software known as medical image processing, analysis, and visualization. The results were compared and a correlation analysis was conducted to investigate which brain areas were related to RLS clinical variables.


Results:

The iron index in the SN was significantly lower in patients with late-onset RLS than in controls (p=0.034), while in patients with early-onset RLS there was no significant difference. There was no significant correlation between the SN iron index of the late-onset RLS group and clinical variables such as disease severity.


Conclusions:

Late-onset RLS is associated with decreased iron content in the SN. This finding supports the hypothesis that regional brain iron deficiency plays a role in the pathophysiology of late-onset RLS.
Keimyung Author(s)(Kor)
문혜진
조용원
장혁원
구정훈
Publisher
School of Medicine
Citation
Hye-Jin Moon et al. (2014). T2 Relaxometry Using 3.0-Tesla Magnetic Resonance Imaging of the Brain in Early- and Late-Onset Restless Legs Syndrome. Journal of Clinical Neurology, 10(3), 197–202. doi: 10.3988/jcn.2014.10.3.197
Type
Article
ISSN
1738-6586
DOI
10.3988/jcn.2014.10.3.197
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33987
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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