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The Effect of Ropinirole on the Quality of Life in Patients with Restless Legs Syndrome in Korea: An 8-Week, Multicenter, Prospective Study

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Author(s)
Yong Won ChoSeung Bong HongDo Hyung KimHo Won LeeEun Yeon JooJee Hyun KimWon Chul ShinKee Hyung ParkSun Jung HanHyang Woon Lee
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Neurology
Issued Date
2013
Volume
9
Issue
1
Keyword
restless legs syndromedopamine agonistsquality of lifesleep
Abstract
Background and Purpose:

Dopamine agonists are first-line drugs for treating the symptoms of restless legs syndrome (RLS). However, few studies have investigated the effect of dopamine agonists on the quality of life (QoL) in RLS patients. We conducted a study to determine whether ropinirole exerts positive effects on the QoL in RLS patients and to analyze the underlying factors.


Methods:

Primary RLS patients from eight medical centers were recruited in the study. They were evaluated in the baseline phase using various questionnaires including the Korean versions of the International Restless Legs Scale (K-IRLS), RLS QoL questionnaire (K-RLSQoL), and the Short Form 36 Health Survey (SF-36). After taking ropinirole for 8 weeks the same questionnaires were again completed as a re-evaluation. We analyzed the statistical difference using a paired t-test, a Pearson's correlation, and a stepwise multiple regression in order to identify the factors associated with the QoL change.


Results:

A total of 107 subjects, including 65 (60.7%) females, completed this study. They were aged 51.68±14.80 years (mean±SD) and had a symptom duration of 8.8±9.0 months. After treatment with ropinirole, there were significant improvements on the K-RLSQoL, SF-36, and K-IRLS. The Pearson's correlation analysis showed that the improvement of QoL in RLS patients was significantly correlated with the severity of RLS (r=0.236, p<0.014) at baseline.


Conclusions:

The results from this study suggest that treatment with ropinirole can improve the QoL in RLS patients. The improvement in the QoL is more related with the improvement of RLS symptoms.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Yong Won Cho et al. (2013). The Effect of Ropinirole on the Quality of Life in Patients with Restless Legs Syndrome in Korea: An 8-Week, Multicenter, Prospective Study. Journal of Clinical Neurology, 9(1), 51–56. doi: 10.3988/jcn.2013.9.1.51
Type
Article
ISSN
1738-6586
DOI
10.3988/jcn.2013.9.1.51
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33988
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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