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Clinical implications of extended-spectrum β-lactamase-producing Klebsiella pneumoniae bacteraemia

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Author(s)
B.-N. KimJ.-H. WooM.-N. KimJ. RyuY. S. Kim
Keimyung Author(s)
Kim, Baek Nam
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Hospital Infection
Issued Date
2002
Volume
52
Issue
2
Keyword
Klebsiella pneumoniaebacteraemiaβ-lactamaseresistance
Abstract
To identify the clinical implications of extended-spectrum b-lactamase (ESBL) production,
162 cases of Klebsiella pneumoniae bacteraemia in 154 adults were analysed. Of these cases, 44 (27.2%) were
ESBL-producing (ESBLKP). Common sources of ESBLKP bacteraemia included primary bacteraemia
(34.1%) and biliary infection (29.5%).The placement of a biliary drainage catheter, nosocomial acquisition, and
prior antibiotic therapy were independently associated with ESBL production in multivariate analysis. More
cases of ESBLKP than non-ESBLKP received inappropriate antibiotic therapy before culture results were
reported (54.5 vs. 3.4%; Pˆ0.001). In 19 cases of ESBLKP, no significant difference in mortality was
observed between patients who received appropriate empiric antibiotic therapy and those who did not (26.3 vs.
20.8%; Pˆ0.67). The mean length of hospital stay after the onset of bacteraemia was longer in the cases of
ESBLKP than in the cases of non-ESBLKP (39.6 vs. 23.9 days; Pˆ0.008). Directly related mortality was not
significantly different between the cases of ESBLKP and the cases of non-ESBLKP (23.3 vs. 20.0%; Pˆ0.65).
None of the patients with biliary infection due to ESBLKP died (0/12; Pˆ0.03). In conclusion, ESBL
production was not significantly associated with death but it had a considerable impact on patients with
K. pneumoniae bacteraemia.
Keimyung Author(s)(Kor)
김백남
Publisher
School of Medicine
Citation
B.-N. Kim et al. (2002). Clinical implications of extended-spectrum β-lactamase-producing Klebsiella pneumoniae bacteraemia. Journal of Hospital Infection, 52(2), 99–106. doi: 10.1053/jhin.2002.1288
Type
Article
ISSN
0195-6701
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0195670102912880?via%3Dihub
DOI
10.1053/jhin.2002.1288
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34047
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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