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Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs

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Author(s)
Yoon Suk JungJae Hee CheonJae Jun ParkChang Mo MoonEun Soo KimJin Ha LeeSeung Won KimJae Hak KimSung Pil HongTae Il KimWon Ho Kim
Keimyung Author(s)
Kim, Eun Soo
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Human Genetics
Issued Date
2010
Volume
55
Issue
2
Keyword
azathioprineinflammatory bowel diseaseinosine triphosphate pyrophosphataserelapsethiopurine S-methyl transferase
Abstract
There is a lack of research describing the associations between thiopurine methyltransferase (TPMT)/inosine triphosphate
pyrophosphatase (ITPA) genotypes and long-term clinical outcomes. We investigated whether TPMT/ITPA genotypes predicted
long-term clinical response in Korean patients with inflammatory bowel diseases (IBDs) undergoing thiopurine treatment.
A total of 204 patients with IBD in whom thiopurine treatment was indicated were enrolled and categorized by TPMT and ITPA
genotypes. Long-term follow-up clinical data for these patients were analyzed with specific focus on disease relapse. Of the
204 patients, 162 (79.4%) patients using thiopurines achieved remission and were included in an analysis of long-term clinical
outcomes. There were no significant differences in disease relapse-free survival between wild and mutant types of TPMT
(P¼0.903) or ITPA (P¼0.392), according to the results of the log-rank analysis. Our study suggests that TPMT and ITPA
genotypes may not affect the rates of disease relapse in IBD patients treated with thiopurines. Further studies are indicated
to confirm the utility of TPMT/ITPA genotyping to guide clinicians formulating individualized treatments for IBD patients
requiring thiopurine therapy.
Keimyung Author(s)(Kor)
김은수
Publisher
School of Medicine
Citation
Yoon Suk Jung et al. (2010). Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs. Journal of Human Genetics, 55(2), 121–123. doi: 10.1038/jhg.2009.125
Type
Article
ISSN
1434-5161
Source
http://www.nature.com/articles/jhg2009125
DOI
10.1038/jhg.2009.125
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34051
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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