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Association of Angiotensin II Type 2 Receptor Gene A1818T Polymorphism with Progression of Immunoglobulin A Nephropathy in Korean Patients

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Author(s)
Hyung Jin YoonHo Jun ChinKi Young NaDong-Wan ChaeSuhnggwon KimUn Sil JeonWoo Kyung ChungHyun Hee LeeJaeseok YangSejoong KimYoung-Joo KwonHyun Chul KimSung Bae ParkHye Young KimTae Woo LeeThe Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) members
Keimyung Author(s)
Kim, Hyun ChulPark, Sung Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2009
Volume
24
Issue
suppl.1
Keyword
PolymorphismSingle NucleotideGlomerulonephritisIGAReceptorAngiotensinType 2
Abstract
We determined the relationship between the progression of immunoglobulin A nephropathy
(IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type
2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of
IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive
REnal disease and Medical Informatics and gEnomics Research (PREMIER)
which was sponsored by the Korean Society of Nephrology. A1818T polymorphism
of AT2R gene was analyzed with PCR-RFLP method and the association
with the progression of IgAN, which was defined as over 50% increase in baseline
serum creatinine level, was analyzed with survival analysis. Among the 480 patients
followed for more than 10 months, the group without T allele had significantly higher
rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024),
although there were no significant differences in the baseline variables such as initial
serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox’s
proportional hazard model, the hazard ratio of disease progression in the patients
with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041)
compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R
gene was associated with the progression of IgAN.
Keimyung Author(s)(Kor)
김현철
박성배
Publisher
School of Medicine
Citation
Hyung Jin Yoon et al. (2009). Association of Angiotensin II Type 2 Receptor Gene A1818T Polymorphism with Progression of Immunoglobulin A Nephropathy in Korean Patients. Journal of Korean Medical Science, 24(suppl.1), S38–S43. doi: 10.3346/jkms.2009.24.S1.S38
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2009.24.S1.S38
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34088
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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