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Clinical and Radiographic Features of Adult-onset Ankylosing Spondylitis in Korean Patients: Comparisons between Males and Females

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Author(s)
Young-Ok JungInje KimSuho KimChang-Hee SuhHan Jung ParkWon ParkSeoung Ryul KwonJae Cheon JeongYun Jong LeeHee Jung RyuYoung Bae ParkJisoo LeeYou-Hyun LeeYoung Il SeoWon Tae ChungSeung-Jae HongYeon-Sik HongHan Joo BaekHyo Jin ChoiHyo-Jong KangChan-Hee LeeSang-Hyon KimHyun Ah Kim
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2010
Volume
25
Issue
4
Keyword
SpondylitisAnkylosing
Abstract
The objective of this study was to investigate clinical and radiographic features and
gender differences in Korean patients with adult-onset ankylosing spondylitis. Multicenter
cross-sectional studies were conducted in the rheumatology clinics of 13 Korean
tertiary referral hospitals. All patients had a confirmed diagnosis of ankylosing
spondylitis according to the modified New York criteria. Clinical, laboratory, and radiographic
features were evaluated and disease activities were assessed using the
Bath ankylosing spondylitis disease activity index. Five hundred and five patients were
recruited. The male to female ratio was 6.1:1. Average age at symptom onset was
25.4±8.9 yr and average disease duration was 9.6±6.8 yr. Males manifested symptoms
at a significantly earlier age. HLA-B27 was more frequently positive in males.
Hips were more commonly affected in males, and knees in females. When spinal
mobility was measured using tragus-to-wall distance and the modified Schober’s
test, females had significantly better results. Radiographic spinal changes, including
bamboo spine and syndesmophytes, were more common in males after adjustment
of confounding factors. In conclusion, we observed significant gender differences
in radiographic spinal involvement as well as other clinical manifestations
among Korea patients with adult-onset ankylosing spondylitis. These findings may
influence the timing of the diagnosis and the choice of treatment.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine
Citation
Young-Ok Jung et al. (2010). Clinical and Radiographic Features of Adult-onset Ankylosing Spondylitis in Korean Patients: Comparisons between Males and Females. Journal of Korean Medical Science, 25(4), 532–535. doi: 10.3346/jkms.2010.25.4.532
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2010.25.4.532
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34093
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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