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Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs

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Author(s)
Young Ho JangJin Mo Kim
Keimyung Author(s)
Jang, Young HoKim, Jin Mo
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of Korean Medical Science
Issued Date
2003
Volume
18
Issue
1
Keyword
Myocardial ReperfusionNicardipine
Abstract
Nicardipine is a potent coronary and systemic vasodilator without depression of
ventricular function. We investigated the changes in local myocardial perfusion
(LMP) according to the nicardipine administration after coronary reperfusion in a
beating canine model. A Doppler probe was placed around the left anterior descending
coronary artery (LAD) and thermal diffusion microprobe was implanted in the
myocardium perfused by the exposed LAD. To define the nicardipine effects, we
compared the two groups (control group, n=7 vs nicardipine group, n=7). In nicardipine
group, 5 g/kg/min nicardipine was infused continuously. After the release of
the LAD occlusion, LAD blood flow were increased compared to the baseline of
both groups. However, there was no difference between groups in the LAD
blood flow. The LMP after LAD reperfusion did not recover to the baseline level
until 30 min after LAD reperfusion in control group (74%, 52% and 70% at 10, 20
and 30 min after LAD reperfusion, respectively). In nicardipine group, however, the
LMP recovered to the baseline level at 20 min (99%), and increased more than
the baseline level at 30 min (141%) after LAD reperfusion. Our findings suggest
that the nicardipine augments the LMP following the release of a coronary occlusion.
Keimyung Author(s)(Kor)
장영호
김진모
Publisher
School of Medicine
Citation
Young Ho Jang and Jin Mo Kim. (2003). Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs. Journal of Korean Medical Science, 18(1), 23–26. doi: 10.3346/jkms.2003.18.1.23
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2003.18.1.23
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34113
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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