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p53 codon 72 polymorphism and risk of cervical carcinoma in Korean women

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Author(s)
Won-Ki BaekJae-We ChoSeong-Il SuhMin-Ho SuhDong-Hoon ShinChi-Heum ChoTae-Sung LeeSoon-Do Cha
Keimyung Author(s)
Baek, Won KiSuh, Seong IlSuh, Min HoShin, Dong HoonCho, Chi HeumLee, Tae SungCha, Soon Do
Department
Dept. of Microbiology (미생물학)
Dept. of Preventive Medicine (예방의학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2000
Volume
15
Issue
1
Keyword
Genes, p53Polymorphism (Genetics)Cervix NeoplasmsPapilomavirus
Abstract
A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro). A recent study suggested that this polymorphism affects the susceptibility of p53 protein to human papillomavirus E6 oncoprotein mediated degradation and that individuals homozygous for p53Arg are seven times more susceptible to HPV-associated carcinogenesis of the cervix than heterozygotes. To examine whether the p53Arg genotype could be a risk factor for HPV-associated cervical carcinomas in the Korean population, we analyzed the p53 codon 72 polymorphism status of HPV-positive invasive cervical carcinomas from 52 Korean women and 103 healthy control samples. The proportion of individuals homozygous for p53Arg, homozygous for p53Pro, and heterozygous for the two alleles were 40%, 19%, and 41% in normal healthy controls; 42%, 17%, and 40% in women with HPV-positive invasive cervical carcinoma. There were no significant differences in the distribution of p53 genotypes between controls and cervical carcinomas. This finding indicates that the p53Arg genotype is not associated with an increased susceptibility to cervical carcinoma in Korean women.
Keimyung Author(s)(Kor)
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서성일
서민호
신동훈
조치흠
이태성
차순도
Publisher
School of Medicine
Citation
Won-Ki Baek et al. (2000). p53 codon 72 polymorphism and risk of cervical carcinoma in Korean women. Journal of Korean Medical Science, 15(1), 65–67. doi: 10.3346/jkms.2000.15.1.65
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2000.15.1.65
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34115
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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