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Postoperative Carcinoembryonic Antigen as a Complementary Tumor Marker of Carbohydrate Antigen 19-9 in Pancreatic Ductal Adenocarcinoma

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Author(s)
Jaihwan KimYoon Suk LeeIn Kyeom HwangBong Kyun KangJai Young ChoYoo-Seok YoonHo-Seong HanJin-Hyeok Hwang
Keimyung Author(s)
Lee, Yoon Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2015
Volume
30
Issue
3
Keyword
Pancreatic NeoplasmsCarcinoembryonic AntigenCA 19-9PrognosisSurvival
Abstract
The role of carcinoembryonic antigen (CEA) in pancreatic cancer remains poorly
understood. Therefore, this study aimed to determine whether CEA is complementary to
carbohydrate antigen 19-9 (CA19-9) in prognosis prediction after pancreatic cancer
curative resection. We retrospectively reviewed records of 144 stage II curatively resected
pancreatic cancer patients with preoperative and postoperative CEA and CA19-9 levels.
Patients with normal preoperative CA19-9 were excluded. R0 resection margin, adjuvant
treatment, and absence of angiolymphatic invasion were associated with better overall
survival. There was no significant difference in median survival according to preoperative
CEA levels. However, patients with normal postoperative CA19-9 (59.8 vs.16.2 months,
P < 0.001) and CEA (29.4 vs. 9.3 months, P = 0.001) levels had longer overall survival
than those with elevated levels. Among 76 patients with high postoperative CA19-9 levels,
a better prognosis was observed in those with normal postoperative CEA levels than in
those with elevated levels (19.1 vs. 9.3 months, P = 0.004). Postoperative CEA and CA19-
9 levels are valuable prognostic markers in resected pancreatic cancer. Normal
postoperative CEA levels indicate longer survival, even in patients with elevated
postoperative CA19-9.
Keimyung Author(s)(Kor)
이윤석
Publisher
School of Medicine
Citation
Jaihwan Kim et al. (2015). Postoperative Carcinoembryonic Antigen as a Complementary Tumor Marker of Carbohydrate Antigen 19-9 in Pancreatic Ductal Adenocarcinoma. Journal of Korean Medical Science, 30(3), 259–263. doi: 10.3346/jkms.2015.30.3.259
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2015.30.3.259
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34117
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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