계명대학교 의학도서관 Repository

Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease

Metadata Downloads
Author(s)
Won Ki HongKwang Yong ShimSoon Koo BaikMoon Young KimMee Yon ChoYoon Ok JangYoung Shik ParkJin HanGaeun KimYoun Zoo ChoHye Won HwangJin Hyung LeeMyeong Hun ChaeSang Ok Kwon
Keimyung Author(s)
Kim, Ga Eun
Department
Dept. of Nursing (간호학)
Journal Title
Journal of Korean Medical Science
Issued Date
2014
Volume
29
Issue
3
Keyword
Hypertension, PortalNitric OxideLiver Cirrhosis
Abstract
Tetrahydrobiopterin (BH4) is an essential cofactor in NO synthesis by endothelial nitric
oxide synthase (eNOS) enzymes. It has been previously suggested that reduced intrahepatic
BH4 results in a decrease in intrahepatic NO and contributes to increased hepatic vascular
resistance and portal pressure in animal models of cirrhosis. The main aim of the present
study was to evaluate the relationship between BH4 and portal hypertension (PHT). One
hundred ninety-three consecutive patients with chronic liver disease were included in the
study. Liver biopsy, measurement of BH4 and hepatic venous pressure gradient (HVPG)
were performed. Hepatic fibrosis was classified using the Laennec fibrosis scoring system.
BH4 levels were determined in homogenized liver tissues of patients using a high
performance liquid chromatography (HPLC) system. Statistical analysis was performed to
evaluate the relationship between BH4 and HVPG, grade of hepatic fibrosis, clinical stage
of cirrhosis, Child-Pugh class. A positive relationship between HVPG and hepatic fibrosis
grade, clinical stage of cirrhosis and Child-Pugh class was observed. However, the BH4
level showed no significant correlation with HVPG or clinical features of cirrhosis. BH4
concentration in liver tissue has little relation to the severity of portal hypertension in
patients with chronic liver disease.
Keimyung Author(s)(Kor)
김가은
Publisher
College of Nursing
Citation
Won Ki Hong et al. (2014). Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease. Journal of Korean Medical Science, 29(3), 392–399. doi: 10.3346/jkms.2014.29.3.392
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2014.29.3.392
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34121
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.