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Serum Pro-hepcidin Could Reflect Disease Activity in Patients with Rheumatoid Arthritis

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Author(s)
Hae-Rim KimKyoung-Woon KimSo-Young YoonSang-Hyon KimSang-Heon Lee
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2010
Volume
25
Issue
3
Keyword
ArthritisRheumatoidAnemiaHepcidinProhepcidin
Abstract
The aim of this study was to analyze the relationship between serum pro-hepcidin concentration and the anemia profiles of rheumatoid arthritis (RA) and to estimate the pro-hepcidin could reflect the disease activity of RA. RA disease activities were measured using Disease Activity Score 28 (DAS28), tender/swollen joint counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Anemia profiles such as hemoglobin, iron, total iron binding capacity (TIBC), ferritin, and transferrin levels were measured. Serum concentration of pro-hepcidin, the prohormone of hepcidin, was measured using enzyme-linked immunosorbent assay (ELISA). Mean concentration of serum pro-hepcidin was 237.6±67.9 ng/mL in 40 RA patients. The pro-hepcidin concentration was correlated with rheumatoid factor, CRP, ESR, and DAS28. There was a significant correlation between pro-hepcidin with tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. The pro-hepcidin concentration was significantly higher in the patients with active RA (DAS28>5.1) than those with inactive to moderate RA (DAS28≤5.1). However, the pro-hepcidin concentration did not correlate with the anemia profiles except hemoglobin level. There was no difference of pro-hepcidin concentration between the patients with anemia of chronic disease and those without. In conclusion, serum concentration of pro-hepcidin reflects the disease activity, regardless of the anemia states in RA patients, thus it may be another potential marker for disease activity of RA.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine
Citation
Hae-Rim Kim et al. (2010). Serum Pro-hepcidin Could Reflect Disease Activity in Patients with Rheumatoid Arthritis. Journal of Korean Medical Science, 25(3), 348–352. doi: 10.3346/jkms.2010.25.3.348
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2010.25.3.348
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34125
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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