Serum Pro-hepcidin Could Reflect Disease Activity in Patients with Rheumatoid Arthritis
- Author(s)
- Hae-Rim Kim; Kyoung-Woon Kim; So-Young Yoon; Sang-Hyon Kim; Sang-Heon Lee
- Keimyung Author(s)
- Kim, Sang Hyon
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- Journal of Korean Medical Science
- Issued Date
- 2010
- Volume
- 25
- Issue
- 3
- Keyword
- Arthritis; Rheumatoid; Anemia; Hepcidin; Prohepcidin
- Abstract
- The aim of this study was to analyze the relationship between serum pro-hepcidin concentration and the anemia profiles of rheumatoid arthritis (RA) and to estimate the pro-hepcidin could reflect the disease activity of RA. RA disease activities were measured using Disease Activity Score 28 (DAS28), tender/swollen joint counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Anemia profiles such as hemoglobin, iron, total iron binding capacity (TIBC), ferritin, and transferrin levels were measured. Serum concentration of pro-hepcidin, the prohormone of hepcidin, was measured using enzyme-linked immunosorbent assay (ELISA). Mean concentration of serum pro-hepcidin was 237.6±67.9 ng/mL in 40 RA patients. The pro-hepcidin concentration was correlated with rheumatoid factor, CRP, ESR, and DAS28. There was a significant correlation between pro-hepcidin with tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. The pro-hepcidin concentration was significantly higher in the patients with active RA (DAS28>5.1) than those with inactive to moderate RA (DAS28≤5.1). However, the pro-hepcidin concentration did not correlate with the anemia profiles except hemoglobin level. There was no difference of pro-hepcidin concentration between the patients with anemia of chronic disease and those without. In conclusion, serum concentration of pro-hepcidin reflects the disease activity, regardless of the anemia states in RA patients, thus it may be another potential marker for disease activity of RA.
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