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Vestibular Schwannoma with Malignant Transformation : A Case Report

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Author(s)
Eun-Ik SonIl-Man KimSang-Pyo Kim
Keimyung Author(s)
Kim, Sang PyoSon, Eun IkKim, El
Department
Dept. of Pathology (병리학)
Dept. of Neurosurgery (신경외과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2001
Volume
16
Issue
6
Keyword
NeuromaAcousticTumor RecurrenceNeurilemmoma
Abstract
We describe a rare case of malignant transformation in a vestibular schwannoma
in a 33-yr-old woman. She presented herself with headache, tinnitus, and
hearing loss and underwent posterior fossa explorations three times during the
short period of 3 months. The clinicopathological features of the original tumor
were typical of benign vestibular schwannoma. Despite a comlpete microsurgical
excision, two months later, the tumor recurred locally with a rapid increase in
size causing a progressive worsening of neurological symptoms. A diagnosis of
malignant schwannoma was made for the recurrent tumor on the basis of the
microscopic findings of high cellularity, moderate pleomorphism, and the presence
of mitotic cells. Repeat magnetic resonance imaging performed a month
after the second surgery unexpectedly showed definite tumor enlargement. She
remained clinically stable following the third debulking of the tumor and adjuvant
radiotherapy. We propose that this recurrent tumor represent malignant transformation
from a benign vestibular schwannoma which was an unusual occurrence
in a patient without neurofibromatosis.
Keimyung Author(s)(Kor)
김상표
손은익
김엘
Publisher
School of Medicine
Citation
Eun-Ik Son et al. (2001). Vestibular Schwannoma with Malignant Transformation : A Case Report. Journal of Korean Medical Science, 16(6), 817–821. doi: 10.3346/jkms.2001.16.6.817
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2001.16.6.817
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34134
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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