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Altered p53 expression in Epstein Barr virus positive T cell lymphomas

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Author(s)
Ju-Hie LeeSang-Sook LeeJune-Sik ParkSun LeeMoon-Ho YangTae-Young Yoon
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Korean Medical Science
Issued Date
1995
Volume
10
Issue
6
Keyword
p53 immunohistochemistyEBV in siteHead
Abstract
Recent studies have suggested a probable association between Epstein-Barr virus (EBV) and nasal/nasopharyngeal T cell lymphomas but the role of oncogenes or tumor suppressor genes is poorly understood. We have studied the frequency of p53 expression and its relation to the EBV infection in 33 Korean patients with head and neck (H&N) lymphomas. All cases (23 B cell & 10 T cell) were immunostained for p53 protein using the mAb D07 (Novocastra) and the avidin biotin peroxidase method. EBER in situ hybridization was performed using a fluorescein conjugated EBV oligonucleotide probe (Dako). Among 33 lymphomas, 16 cases stained positively for p53 protein. P53 expression was frequent both in higher grade lymphomas and in advanced stage. Nine cases were EBER positive, EBER was more commonly found in T cell lymphomas than in B cell lymphomas (70% vs 8.7%). EBER positive lymphomas showed a higher frequency of p53 positivity than EBER negative lymphomas (78% vs 38%), although the difference was not statistically significant (p = 0.095). These findings indicate altered expression of p53 protein occurs in H&N lymphomas, especially in late event lymphoma progression and appears to play a role in the development of EBER positive T cell lymphomas.
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
Ju-Hie Lee et al. (1995). Altered p53 expression in Epstein Barr virus positive T cell lymphomas. Journal of Korean Medical Science, 10(6), 399–405. doi: 10.3346/jkms.1995.10.6.399
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.1995.10.6.399
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34136
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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