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Enhancement of the Liver and Pancreas in the Hepatic Arterial Dominant Phase: Comparison of Hepatocyte-Specific MRI Contrast Agents, Gadoxetic Acid and Gadobenate Dimeglumine, on 3 and 1.5 Tesla MRI in the Same Patient

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Author(s)
Hee Jin KimBong Soo KimMi Jeong KimSeong Hyun KimRafael O.P. de CamposMateus HernandesRichard C. Semelka
Keimyung Author(s)
Kim, Mi Jeong
Department
Dept. of Radiology (영상의학)
Journal Title
Journal of Magnetic Resonance Imaging
Issued Date
2013
Volume
37
Issue
4
Keyword
contrast mediagadoxetic acidgadobenate dimegluminegadoliniummagnetic resonance imagingabdominal imaging
Abstract
Purpose: To evaluate the relative enhancement of liver,
pancreas, focal nodular hyperplasia (FNH), pancreas-toliver
index, and FNH-to-liver index in the hepatic arterial
dominant phase (HADP) after injection of hepatocyte-specific
MRI contrast agents, gadoxetic acid and gadobenate
dimeglumine, on 3 and 1.5 Tesla (T) MRI in the same
patient.
Materials and Methods: The MRI database was retrospectively
searched to identify consecutive patients who
underwent abdominal MRI at 3T and 1.5T systems, using
both 0.025 mmol/kg gadoxetic acid-enhanced and 0.05
mmol/kg gadobenate dimeglumine-enhanced MRI at the
same magnetic strength field system. 22 patients were
identified, 10 were scanned at 3T system and 12 at 1.5T
system. The enhancement of liver, pancreas, and FNH
was evaluated quantitatively on MR images.
Results: The relative enhancement of liver in HADP in the
gadobenate dimeglumine-enhanced group in all subjects
was significantly higher than that in gadoxetic acidenhanced
group (P ¼ 0.023). The gadobenate dimeglumine-
enhanced group in HADP had better relative
enhancement of pancreas and FNH, pancreas-to-liver
index, and FNH-to-liver index than gadoxetic acidenhanced
group, but the difference was not statistically
significant.
Conclusion: The 0.05 mmol/kg gadobenate dimeglumine-
enhanced abdominal MRI studies at 3T and 1.5T
MR systems are superior in relative enhancement of the
liver in HADP to 0.025 mmol/kg gadoxetic acid-enhanced
MRI. This type of assessment may provide comparative
effectiveness data.
Keimyung Author(s)(Kor)
김미정
Publisher
School of Medicine
Citation
Hee Jin Kim et al. (2013). Enhancement of the Liver and Pancreas in the Hepatic Arterial Dominant Phase: Comparison of Hepatocyte-Specific MRI Contrast Agents, Gadoxetic Acid and Gadobenate Dimeglumine, on 3 and 1.5 Tesla MRI in the Same Patient. Journal of Magnetic Resonance Imaging, 37(4), 903–908. doi: 10.1002/jmri.23874
Type
Article
ISSN
1053-1807
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23874
DOI
10.1002/jmri.23874
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34155
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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