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Pallidal Index Measured with Three-Dimensional T1-Weighted Gradient Echo Sequence is a Good Predictor of Manganese Exposure in Welders

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Author(s)
Yongmin ChangSeung-Tae WooYangho KimJae-Jun LeeHui-Jin SongHui Joong LeeSuk Hwan KimHun LeeYoung Joo KwonJoon-Ho AhnSin-Jae ParkIn-Sung ChungKyoung Sook Jeong
Keimyung Author(s)
Chung, In Sung
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
Journal of Magnetic Resonance Imaging
Issued Date
2010
Volume
31
Issue
4
Keyword
manganeseneurobehavioral performanceMRIpallidal index (PI)
Abstract
Purpose: To evaluate which T1-wieghted technique
between 3D gradient-echo (FSPGR) and conventional
spin-echo (SE) sequence is more sensitive predictor of
neurobehavioral dysfunction found in welders with
chronic manganese (Mn) acquired at 3 Tesla.
Materials and Methods: Forty-three current male welders
and 29 age- and gender-matched, nonwelding production
workers (control individuals) were recruited to the present
study. Each subject underwent neurological examination,
blood sample collection, and neurobehavioral tests, in
addition to magnetic resonance imaging (MRI) examination.
The MRI examinations were performed using a 3.0
Tesla whole-body scanner. T1-weighted axial images were
obtained using SE and FSPGR with a 180 inversion recovery
prepared pulse, and the corresponding pallidal
indices (PI), PI (SE), and PI (FSPGR), were calculated.
Results: Both PI (SE) and PI (FSPGR) were well correlated
with blood Mn level, but only PI (FSPGR) was significantly
correlated with air Mn concentration (P ¼ 0.007). Of the
neurobehavioral performance indicators, after controlling
for covariates, PI (FSPGR) was significantly associated
with cognitive components, such as the digit symbol
score, the digit span backward score, the Stroop test
score and also with the grooved pegboard (dominant
hand) score, whereas PI (SE) was associated only with
grooved pegboard (dominant hand) score.
Conclusion: PI using a T1-weighted 3D FSPGR sequence
shows the best correlation with neurobehavioral performance
indicators and is the best measure for detection of
blood and airborne Mn concentrations in welders exposed
to excessive occupational Mn.
Keimyung Author(s)(Kor)
정인성
Publisher
School of Medicine
Citation
Yongmin Chang et al. (2010). Pallidal Index Measured with Three-Dimensional
T1-Weighted Gradient Echo Sequence is a Good
Predictor of Manganese Exposure in Welders. Journal of Magnetic Resonance Imaging, 31(4), 1020–1026. doi: 10.1002/jmri.22104
Type
Article
ISSN
1053-1807
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.22104
DOI
10.1002/jmri.22104
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34158
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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