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Diferuloylputrescine, a Predominant Phenolic Amide in Corn Bran, Potently Induces Apoptosis in Human Leukemia U937 Cells

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Author(s)
Eun-Ok KimTaeg-Kyu KwonSang-Won Choi
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Journal of Medicinal Food
Issued Date
2014
Volume
17
Issue
5
Keyword
anticancer activityapoptosiscorn brandiferuloylputrescine
Abstract
The purpose of this study was to investigate how proliferation and apoptosis in human leukemia U937 cells are
affected by four hydroxycinnamic acid derivatives (HCADs) in corn (Zea mays L.) bran: p-coumaric (CA), ferulic acids (FA),
dicoumaroylputrescine (DCP), and diferuloylputrescine (DFP). Of the four HCADs, DFP dose dependently exerted the
strongest cytotoxic effect and induction of apoptosis in the U937 cells. In addition, DFP induced distinct morphological
changes characteristic of cellular apoptosis, such as chromatin condensation, apoptotic bodies, and DNA fragmentations. The
DFP-induced apoptosis was also associated with released cytochrome c in the cytosol with activation of caspase 3, together
with the downregulation of anti-apoptotic proteins, including XIAP and cIAP2, Bcl-2, and Mcl-1. Finally, the DFP-induced
apoptosis was a cell-specific response in leukemia cells, as compared with those of other cancer cells, such as Caki, HT29, SKHep1,
and MDA-MB231. Thus, these results suggest that DFP may be useful as a potential source of natural antileukemic
agents.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Eun-Ok Kim et al. (2014). Diferuloylputrescine, a Predominant Phenolic Amide in Corn Bran, Potently Induces Apoptosis in Human Leukemia U937 Cells. Journal of Medicinal Food, 17(5), 519–526. doi: 10.1089/jmf.2013.2913
Type
Article
ISSN
1096-620X
Source
https://www.liebertpub.com/doi/abs/10.1089/jmf.2013.2913
DOI
10.1089/jmf.2013.2913
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34165
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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