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Persistent Expression of Fas/FasL mRNA in the Mouse Hippocampus After a Single NMDA Injection

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Author(s)
Song-Woo ShinJong-Wook ParkMin-Ho SuhSung-Il SuhByung-Kil Choe
Keimyung Author(s)
Park, Jong WookChoe, Byung KilSuh, Min HoSuh, Seong Il
Department
Dept. of Immunology (면역학)
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Journal Title
Journal of Neurochemistry
Issued Date
1998
Volume
71
Issue
4
Keyword
NMDALong-term gene expressionHippocampus
Abstract
Synaptic reorganization plays a very important role in brain adaptations to environmental stimuli, diseases, and aging processes. The NMDA model of excitotoxic injury was used to investigate the long-term molecular changes in the surviving neural cells in the mouse hippocampus. We demonstrated that a single intraperitoneal injection of NMDA produces persistent expression of c-fos, c-jun, Fas, and Fas ligand (FasL) mRNA in the hippocampus for 5 months. To determine the cellular origin of those gene transcripts in our in vivo model, a glial cell line and primary fetal neuronal culture were used to investigate the inducibility of the c-fos, c-jun, Fas, and FasL mRNA by NMDA. Both c-fos and Fas mRNA expression was observed in the NMDA-treated glial or neuronal cultures; however, c-jun and FasL mRNA was undetectable in this study. In our in vivo model, mossy fiber sprouting and apoptosis were also observed up to 40 days after the NMDA injection. Therefore, we hypothesize that the observed long-term expression of c-fos, c-jun, Fas, and FasL mRNAs may reflect the ongoing synaptic reorganization.
Keimyung Author(s)(Kor)
박종욱
최병길
서민호
서성일
Publisher
School of Medicine
Citation
Song-Woo Shin et al. (1998). Persistent Expression of Fas/FasL mRNA in the Mouse Hippocampus After a Single NMDA Injection. Journal of Neurochemistry, 71(4), 1773–1776. doi: 10.1046/j.1471-4159.1998.71041773.x
Type
Article
ISSN
0022-3042
DOI
10.1046/j.1471-4159.1998.71041773.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34173
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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