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AMBIVALENT ROLE OF GALLATED CATECHINS IN GLUCOSE TOLERANCE IN HUMANS: A NOVEL INSIGHT INTO NON-ABSORBABLE GALLATED CATECHIN-DERIVED INHIBITORS OF GLUCOSE ABSORPTION

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Author(s)
J.H. PARKJ.Y. JINW.K. BAEKS.H. PARKH.Y. SUNGY.K. KIMJ. LEED.K. SONG
Keimyung Author(s)
Baek, Won KiPark, Jae HyungSong, Dae Kyu
Department
Dept. of Microbiology (미생물학)
Dept. of Physiology (생리학)
Journal Title
Journal of Physiology and Pharmacology
Issued Date
2009
Volume
60
Issue
4
Keyword
gallated catechintype 2 diabetesobesityglucose absorptioninsulin resistanceglucose uptake
Abstract
Prolonged postprandial hyperglycemia is a detrimental factor for type 2 diabetes and obesity. The benefit of green tea
extract (GTE) consumption still requires confirmation. We report the effects of circulating green tea catechins on blood
glucose and insulin levels. Oral glucose loading 1 h after GTE ingestion in humans led to higher blood glucose and
insulin levels than in control subjects. Gallated catechins were required for these effects, although within the intestinal
lumen they have been known to decrease glucose and cholesterol absorption. Treatment with epigallocatechin-3-gallate
hindered 2-deoxyglucose uptake into liver, fat, pancreatic beta-cell, and skeletal muscle cell lines. The glucose
intolerance was ameliorated by gallated catechin-deficient GTE or GTE mixed with polyethylene glycol, which was
used as an inhibitor of intestinal absorption of gallated catechins. These findings may suggest that the gallated catechin
when it is in the circulation elevates blood glucose level by blocking normal glucose uptake into the tissues, resulting in
secondary hyperinsulinemia, whereas it decreases glucose entry into the circulation when they are inside the intestinal
lumen. These findings encourage the development of non-absorbable derivatives of gallated catechins for preventative
treatment of type 2 diabetes and obesity, which would specifically induce only the positive luminal effect.
Keimyung Author(s)(Kor)
백원기
박재형
송대규
Publisher
School of Medicine
Citation
J.H. PARK et al. (2009). AMBIVALENT ROLE OF GALLATED CATECHINS IN GLUCOSE TOLERANCE
IN HUMANS: A NOVEL INSIGHT INTO NON-ABSORBABLE GALLATED
CATECHIN-DERIVED INHIBITORS OF GLUCOSE ABSORPTION. Journal of Physiology and Pharmacology, 60(4), 101–109.
Type
Article
ISSN
1899-1505
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34235
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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