계명대학교 의학도서관 Repository

Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity

Metadata Downloads
Author(s)
Kyoung-Jin MinJi Hoon JangTaeg Kyu Kwon
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Journal of Pineal Research
Issued Date
2012
Volume
52
Issue
3
Keyword
AktCC chemokinemelatoninNF-jBSTAT
Abstract
Melatonin influences sleep and circadian rhythm, and it has anti-inflammatory functions. However, the mechanism of its anti-inflammatory roles is not well understood. In our studies, we show that melatonin blocked lipopolysaccharide (LPS)-induced CCL2 (monocyte chemotactic protein-1; MCP-1), CCL5 (Regulated upon Activation, Normal T-cell Expressed, and Secreted), and CCL9 (macrophage inflammatory protein-1γ) chemokine mRNA expression in BV2 murine microglial cells. Melatonin markedly inhibited LPS-induced Akt phosphorylation and NF-κB activation. Furthermore, melatonin inhibited LPS-induced STAT1/3 phosphorylation and interferon-gamma activated sequence (GAS)-driven transcriptional activity. Interestingly, these effects were not associated with reactive oxygen species scavenging effects of melatonin or melatonin receptor signal pathways. Taken together, our results suggested that melatonin has anti-inflammatory functions through down-regulation of chemokine expression by inhibition of NF-κB and STAT/GAS activation in LPS-stimulated BV2 murine microglial cell line.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Kyoung-Jin Min et al. (2012). Inhibitory effects of melatonin on the lipopolysaccharide-induced
CC chemokine expression in BV2 murine microglial cells are
mediated by suppression of Akt-induced NF-κB and STAT/GAS activity. Journal of Pineal Research, 52(3), 296–304. doi: 10.1111/j.1600-079X.2011.00943.x
Type
Article
ISSN
0742-3098
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/j.1600-079X.2011.00943.x
DOI
10.1111/j.1600-079X.2011.00943.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34236
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.