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Is Microsatellite Instability a Prognostic Marker in Gastric Cancer?: A Systematic Review With Meta-Analysis

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Author(s)
YOON YOUNG CHOIJUNG MIN BAEJI YEONG ANIN GYU KWONIN CHOHYUN BEAK SHINTANAKA EIJIMOHAMMAD ABURAHMAHHYUNG-IL KIMJAE-HO CHEONGWOO JIN HYUNGSUNG HOON NOH
Keimyung Author(s)
Kwon, In Gyu
Department
Dept. of Surgery (외과학)
Journal Title
Journal of Surgical Oncology
Issued Date
2014
Volume
110
Issue
2
Keyword
MSIgastric cancerprognosis
Abstract
Background and Objective:

The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta-analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer.


Methods:

A comprehensive systematic review and meta-analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to “microsatellite instability,” “gastric cancer,” and “prognosis.”


Results:

Twenty-four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non-MSI was 0.72 (95%CI: 0.59–0.88, P = .001) in a random-effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity.


Conclusion:

MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies.
Keimyung Author(s)(Kor)
권인규
Publisher
School of Medicine
Citation
YOON YOUNG CHOI et al. (2014). Is Microsatellite Instability a Prognostic Marker in Gastric Cancer?: A Systematic Review With Meta-Analysis. Journal of Surgical Oncology, 110(2), 129–135. doi: 10.1002/jso.23618
Type
Article
ISSN
0022-4790
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.23618
DOI
10.1002/jso.23618
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34261
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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