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Tissue Doppler Imaging as a Prognostic Marker for Cardiovascular Events in Heart Failure with Preserved Ejection Fraction and Atrial Fibrillation

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Author(s)
Hong-Won ShinHyungseop KimJihyun SonHyuck-Jun YoonHyoung-Seob ParkYun-Kyeong ChoChun-Duk HanChang-Wook NamSeung-Ho HurYoon-Nyun KimKwon-Bae Kim
Keimyung Author(s)
Kim, Hyung SeopYoon, Hyuck JunPark, Hyoung SeobCho, Yun KyeongNam, Chang WookHur, Seung HoKim, Yoon NyunKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of the American Society of Echocardiography
Issued Date
2010
Volume
23
Issue
7
Keyword
Atrial fibrillationEchocardiographyHeart failureTissue Doppler imaging
Abstract
Background:

Although atrial fibrillation (AF) is associated with adverse cardiovascular (CV) outcomes, the prognosis of heart failure (HF) with preserved ejection fraction (HFPEF) with AF is still uncertain. This study was designed to evaluate whether the occurrence of CV events in patients with HFPEF and AF could be predicted by tissue Doppler imaging (TDI) of mitral annular velocity.


Methods:

Clinical and echocardiographic data from January 2004 to December 2005 in patients with HFPEF and AF were investigated in this retrospective study. The development of CV events was defined as the composite of CV death, recurrent HF, and ischemic stroke.


Results:

Of 148 patients (mean age 68 ± 10 years; 64% were men), 35 clinical events, including 2 cardiac deaths, 22 recurrent HFs, and 11 ischemic strokes, were identified during a median follow-up of 27 months. In univariate analyses, age, ejection fraction, left atrial dimension, systolic (s'), and early diastolic (e') mitral annular velocities were correlated with clinical events. Multivariate analyses revealed that old age, enlarged left atrial dimension, and lower s' and e' remained independent predictors of outcomes. Furthermore, patients with both s' < 5 cm/s and e' < 7 cm/s experienced more frequent clinical events (hazard ratio 12.2; 95% confidence interval, 1.62-92.5; P = .015).


Conclusion:

s' and e', particularly their combination, seem to be useful predictors of CV events in patients with HFPEF with AF.
Keimyung Author(s)(Kor)
김형섭
윤혁준
박형섭
조윤경
남창욱
허승호
김윤년
김권배
Publisher
School of Medicine
Citation
Hong-Won Shin et al. (2010). Tissue Doppler Imaging as a Prognostic Marker for
Cardiovascular Events in Heart Failure with Preserved
Ejection Fraction and Atrial Fibrillation. Journal of the American Society of Echocardiography, 23(7), 755–761. doi: 10.1016/j.echo.2010.05.003
Type
Article
ISSN
0894-7317
Source
http://lps3.linkinghub.elsevier.com.proxy.dsmc.or.kr/retrieve/pii/S0894-7317(10)00365-2
DOI
10.1016/j.echo.2010.05.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34264
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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