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Risk Factors for the Development of Clostridium difficileassociated Colitis after Colorectal Cancer Surgery

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Author(s)
Chang Ho YeomMin Mi ChoSeong Kyu BaekOk Suk Bae
Keimyung Author(s)
Baek, Seong KyuBae, Ok Suk
Department
Dept. of Surgery (외과학)
Journal Title
Journal of the Korean Society of Coloproctology
Issued Date
2010
Volume
26
Issue
5
Keyword
Clostridium difficileColitisColorectal cancer
Abstract
Purpose:

Clostridium difficile (C. difficile)-associated colitis, a known complication of colon and rectal surgery, can increase perioperative morbidity and mortality, leading to increased hospital stay and costs. Several contributing factors, including advanced age, mechanical bowel preparation, and antibiotics, have been implicated in this condition. The purpose of this study was to determine the clinical features of and factors responsible for C. difficile-associated colitis after colorectal cancer surgery.


Methods:

The medical records of patients who had undergone elective resection for colorectal cancer from January 2008 to April 2010 were reviewed. Cases that involved procedures such as transanal excision, stoma creation, or emergency operation were excluded from the analysis.


Results:

Resection with primary anastomosis was performed in 219 patients with colorectal cancer. The rate of postoperative C. difficile-associated colitis was 6.8% in the entire study population. Preoperative metallic stent insertion (P = 0.017) and aged sixty and older (≥ 60, P = 0.025) were identified as risk factors for postoperative C. difficile-associated colitis. There were no significant differences in variables such as preoperative oral non-absorbable antibiotics, site of operation, operation procedure, and duration of prophylactic antibiotics.


Conclusion:

Among the potential causative factors of postoperative C. difficile-associated colitis, preoperative metallic stent insertion and aged sixty and older were identified as risk factors on the basis of our data. Strategies to prevent C. difficile infection should be carried out in patients who have undergone preoperative insertion of a metallic stent and are aged sixty and older years.
Keimyung Author(s)(Kor)
백성규
배옥석
Publisher
School of Medicine
Citation
Chang Ho Yeom et al. (2010). Risk Factors for the Development of Clostridium difficileassociated Colitis after Colorectal Cancer Surgery. Journal of the Korean Society of Coloproctology, 26(5), 329–333. doi: 10.3393/jksc.2010.26.5.329
Type
Article
ISSN
2093-7822
DOI
10.3393/jksc.2010.26.5.329
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34275
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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