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CR1, ABCA7, andAPOE genes affect the features of cognitive impairment in Alzheimer's disease

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Author(s)
Sun Ju ChungMi-Jung KimYoung Jin KimJuyeon KimSooyeoun YouEun Hye JangSeong Yoon KimJae-Hong Lee
Keimyung Author(s)
You, Soo Yeoun
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of the Neurological Sciences
Issued Date
2014
Volume
339
Issue
1-2
Keyword
Alzheimer's diseaseABCA7APOECR1Single nucleotide polymorphismPhenotype
Abstract
ackground:

The genetic factors that determine the heterogeneity of cognitive impairment in Alzheimer's disease (AD) patients have been rarely reported. We aimed to investigate the association between top hits of genome-wide association studies (GWAS) and specific cognitive domains in AD patients.


Methods:

We investigated 86 single nucleotide polymorphisms (SNPs) selected from 12 genes (ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, LRAT, MS4A6A, PCDH11X, and PICALM) based on results of the recent GWAS and genotyped in 211 AD cases. We also analyzed results of comprehensive neuropsychological evaluations in all cases. We performed multiple regression analyses.


Results:

There were four significant associations between genotypes and phenotypes of AD patients: CR1 SNP rs11803956 correlated with Mini-Mental State Examination (MMSE) score (β = 1.718, Pcorrected = 0.002); ABCA7 SNP rs3752232 correlated with Rey Complex Figure Test (RCFT) copy score (β = − 6.861, Pcorrected = 0.013); APOE SNP rs2075650 correlated with the percentile of RCFT copy score (β = 14.005, Pcorrected = 0.021) and the percentile of total score in phonemic fluency (β = 11.052, Pcorrected = 0.035).


Conclusion:

Our results suggest that CR1, ABCA7, and APOE correlate with specific aspects of cognitive impairments in AD patients.
Keimyung Author(s)(Kor)
유수연
Publisher
School of Medicine
Citation
Sun Ju Chung et al. (2014). CR1, ABCA7, andAPOE genes affect the features of cognitive impairment in Alzheimer’s disease. Journal of the Neurological Sciences, 339(1–2), 91–96. doi: 10.1016/j.jns.2014.01.029
Type
Article
ISSN
0022-510X
Source
https://www.sciencedirect.com/science/article/pii/S0022510X14000537?via%3Dihub
DOI
10.1016/j.jns.2014.01.029
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34299
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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