계명대학교 의학도서관 Repository

Expression of E-Cadherin and uPA and their Association with the Prognosis of Pancreatic Cancer

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Author(s)
Sang Joon ShinKyeong Ok KimMin Kyoung KimKyung Hee LeeMyung Soo HyunKeuk Jun KimJoon Hyuk ChoiHong Seok Song
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Japanese Journal of Clinical Oncology
Issued Date
2005
Volume
35
Issue
6
Keyword
pancreatic neopla는E-cadherinsurokinase plasminogen activator
Abstract
Objective: E-cadherin (ECD) and urokinase plasminogen activator (uPA) have been noted as markers for tumor metastasis and prognosis in several tumors. We thus investigated the relationship between the expression of ECD and uPA and the clinicopathological characteristics in pancreatic cancer.

Methods: The expression of ECD and uPA was evaluated in pancreatic cancer tissues from 53 patients.

Results: Among 53 tumor tissues, those from 29 (54.7%) patients showed positive ECD expression and those from 22 (41.5%) patients showed positive expression of uPA. There were four subgroups of ECD/uPA expression: ECD-positive/uPA-negative, ECD-negative/uPA-negative, ECD-positive/uPA-positive and ECD-negative/uPA-positive. These patterns were found in 14 (26.4%), 11 (20.8%), nine (17%) and 19 (35.8%) patients, respectively. The tumor tissues with ECD-negative and uPA-positive expression were associated with larger tumor, distant metastasis and an increased clinical stage. There was a difference in the median survival time between the patients with ECD-positive/uPA-negative pancreatic tissues (median: 18.7 months) and the patients with ECD-negative/uPA-positive pancreatic tissues (median: 7.5 months, P < 0.05), and there was a statistically significant difference in survival curves between these two groups.

Conclusion: The combined analysis concerning uPA and E-cadherin expression may be a useful predictor of metastasis in pancreactic cancer.
Keimyung Author(s)(Kor)
송홍석
Publisher
School of Medicine
Citation
Sang Joon Shin et al. (2005). Expression of E-Cadherin and uPA and their Association with the Prognosis of Pancreatic Cancer. Japanese Journal of Clinical Oncology, 35(6), 342–348. doi: 10.1093/jjco/hyi094
Type
Article
ISSN
0368-2811
DOI
10.1093/jjco/hyi094
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34307
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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