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Tissue-Engineered Skin Substitutes Using Collagen Scaffold with Amniotic Membrane Component

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Author(s)
Eun Kyung YangJung Keug ParkJae Il AhnHee Gu LeeSeong Jun SeoDae Gu SonJae Chan KimKye Yong Song
Keimyung Author(s)
Son, Dae Gu
Department
Dept. of Plastic Surgery (성형외과학)
Journal Title
Key Engineering Materials
Issued Date
2005
Volume
277-279
Abstract
Human skin substitutes are needed for implantation and wound repair based on the new concept of tissue engineering in combination with biomaterials and cell biological technology. However, failure sometimes occurs when the wound healing is delayed in vivo due to acute inflammation resulting from the early degradation of the transplanted biomaterials. Accordingly, the current study modified conventional biomaterials to overcome early degradation and strong inflammation. In a conventional skin substitute, the animal origin collagenous materials have a slight antigenicity as xenogenic materials, however, the modified method was able to obtain a low antigenicity and anti-inflammation effect using atelo-collagen and an amniotic component. The tyrosine content in the developed atelo-collagen, representing the antigenicity, was reduced from 0.590% to 0.046% based on an HPLC analysis. In addition, to reduce the inflammation and foreign material reaction, an amniotic component was applied to the atelo-collagen materials. While, to enhance the wound healing, the modified skin substitute was developed as a composite matrix of an atelo-collagen scaffold with an amniotic membrane component. A quantitative analysis of hEGF in the amniotic membrane was also performed using different processing methods. Finally, a tissueengineered skin substitute was constructed by cultivating skin cells in the collagen scaffold attached to an amniotic membrane.
Keimyung Author(s)(Kor)
손대구
Publisher
School of Medicine
Citation
Eun Kyung Yang et al. (2005). Tissue-Engineered Skin Substitutes Using Collagen Scaffold with Amniotic Membrane Component. Key Engineering Materials, 277–279, 12–18. doi: 10.4028/www.scientific.net/KEM.277-279.12
Type
Article
ISSN
1662-9795
Source
https://www.scientific.net/KEM.277-279.12
DOI
10.4028/www.scientific.net/KEM.277-279.12
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34311
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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