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Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy

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Author(s)
George BakrisEllen BurgessMatthew WeirGiora DavidaiStephen KovalAMADEO Study Investigators
Keimyung Author(s)
Kim, Hye Soon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Kidney International
Issued Date
2008
Volume
74
Issue
3
Keyword
angiotensin receptor blockerslosartanproteinuriatelmisartantype-2 diabetes
Abstract
In patients with diabetic nephropathy, lowering blood pressure and reducing proteinuria by over 30% correlates with a slower progression to kidney failure. We compared two different angiotensin receptor-blockers in a double blind, prospective trial of 860 patients with type 2 diabetes whose blood pressure levels was over 130/80 mmHg or who were receiving antihypertensive medication(s) and who had a morning spot urinary protein to creatinine ratio of 700 or more. Patients were randomized to telmisartan (a highly lipophilic agent with a long half-life) or losartan (with low lipophilicity and short half-life). The primary endpoint was the difference in the urinary albumin to creatinine ratio between the groups at 52 weeks. The geometric coefficient of variation and the mean of the urinary albumin to creatinine ratio fell in both groups at 52 weeks but both were significantly greater for the telmisartan compared to the losartan cohort. Mean systolic blood pressure reductions were not significantly different between groups at trial end. We conclude that telmisartan is superior to losartan in reducing proteinuria in hypertensive patients with diabetic nephropathy, despite a similar reduction in blood pressure.
Keimyung Author(s)(Kor)
김혜순
Publisher
School of Medicine
Citation
George Bakris et al. (2008). Telmisartan is more effective than losartan in
reducing proteinuria in patients with diabetic
nephropathy. Kidney International, 74(3), 364–369. doi: 10.1038/ki.2008.204
Type
Article
ISSN
0085-2538
DOI
10.1038/ki.2008.204
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34313
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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