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무증상적 요이상을 보인 성인 환자의 임상 경과

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Author(s)
최고황은아여상목백진혁박성배한승엽김현철최미선
Keimyung Author(s)
Hwang, Eun AhPark, Sung BaeHan, Seung YeupKim, Hyun ChulChoe, Mi Sun
Department
Dept. of Pathology (병리학)
Kidney Institute (신장연구소)
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Nephrology
Issued Date
2011
Volume
30
Issue
4
Keyword
ProteinuriaHematuriaRenal failureChronic
Abstract
Purpose: Urinalysis is one of the best methods for early detection of renal disease and recent wide- spread use of mass screening led to increasing prevalence of asymptomatic urinary abnormalities. Usually, primary chronic glomerulonephritis first presents with asymptomatic urinary abnormalities and chronic glomerulonephritis commonly causes end-stage renal disease. However, clinical outcome of asymptomatic urinary abnormalities in adults is not well known. Methods: Between Jan 1995 to Aug 2009, 333 patients with asymptomatic urinary abnormalities who underwent percutaneous renal biopsy were enrolled. A retrospective study was performed to clarify the prognostic factors and the long-term renal outcome of this disease. Results: According to clinical manifestation, there were 79 (23.7%) of isolated microscopic hematuria, 30 (9.0%) of isolated proteinuria and 224 (67.3%) of mixed hematuria and proteinuria. The patients were significantly younger in case with microscopic hematuria. Group with microscopic hematuria had significantly shorter follow up period (p=0.013). In pathologic diagnosis, IgA nephropathy was most common with 244 patients (73.3%). The proteinuria group and mixed group showed significantly higher rate of progression to chronic renal failure than the microscopic hematuria group (p=0.015). The group that 24-hour proteinuria was more than 0.5 g/day showed significantly higher progression rate to chronic renal failure (p<0.000). Using univariate regression analysis, 3 risk factors for progression to chronic renal failure were identified: age, serum creatinine, 24-hour total urine protein. In multivariate regression analysis, only 24-hour proteinuria was the independent prognostic factor for progression to chronic renal failure. Conclusion: IgA nephropathy is the most common cause of asymptomatic urinary abnormalities in adults. The group of proteinuria has higher progression rate to chronic renal failure than other groups. Over 0.5 gm of 24-hour proteinuria is a significant risk factor for progression to chronic renal failure in multivariate regression analysis.
Alternative Title
Clinical outcomes of Asymptomatic Urinary Abnormalities in Adults
Keimyung Author(s)(Kor)
황은아
박성배
한승엽
김현철
최미선
Publisher
School of Medicine
Citation
최고 et al. (2011). 무증상적 요이상을 보인 성인 환자의 임상 경과. Korean Journal of Nephrology, 30(4), 368–376.
Type
Article
ISSN
1225-0015
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34317
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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