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Gene expression of central and peripheral renin-angiotensin system components upon dietary sodium intake in rats

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Author(s)
Hakryul JoEun-Kyoung YangWon-Jung LeeKeun-Yong ParkHyeong-Jin KimJae-Sik Park
Keimyung Author(s)
Park, Keun Yong
Department
Dept. of Internal Medicine (내과학)
Journal Title
Regulatory Peptides
Issued Date
1996
Volume
67
Issue
2
Abstract
The effects of dietary sodium intake on the gene expression of the renin-angiotensin system (RAS) were investigated in rat central and peripheral tissues in a single set of experiment. Northern and reverse transcriptase-polymerase chain reaction (RT-PCR) techniques were used to detect mRNA expression in rats fed a low- or a high-sodium diet (5 or 500 mmol Na +/kg diet) for 20 days. Plasma and renal renin levels were elevated in rats maintained on the low-sodium diet. Sodium deprivation enhanced the expression of angiotensinogen, renin, AT 1A and AT 1B receptor subtypes in the hypothalamus, but suppressed them in the brainstem. Kidney and adrenal levels of those mRNAs were also enhanced in the sodium-restricted rats. Both AT 1A and AT 1B mRNAs changed in a similar magnitude in each tissue examined upon dietary sodium intake. AT 1A was the predominant receptor subtype of AT 1 in all the tissues examined in the present study except the adrenal gland. The present study demonstrated that dietary sodium modulated the gene expression of the RAS components in the central and peripheral tissues. It also showed that the RAS components in the brainstem and hypothalamus were differentially expressed upon sodium deprivation. This suggests different roles of the RAS in these tissues in maintaining body fluid homeostasis in response to different sodium intakes.
Keimyung Author(s)(Kor)
박근용
Publisher
School of Medicine
Citation
Hakryul Jo et al. (1996). Gene expression of central and peripheral renin-angiotensin system components upon dietary sodium intake in rats. Regulatory Peptides, 67(2), 115–121. doi: 10.1016/S0167-0115(96)00119-X
Type
Article
ISSN
0167-0115
Source
https://www.sciencedirect.com/science/article/pii/S016701159600119X?via%3Dihub
DOI
10.1016/S0167-0115(96)00119-X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34332
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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