Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis
- Author(s)
- Jihye Bang; Hyuk Won Chang; Hae-Ra Jung; Chul-Hyun Cho; Ji-An Hur; Sang-Il Lee; Tae Hyun Choi; Sang-Hyon Kim; Eunyoung Ha
- Keimyung Author(s)
- Chang, Hyuk Won; Ha, Eun Young; Jung, Hye Ra; Cho, Chul Hyun; Kim, Sang Hyon; Choi, Tae Hyun
- Department
- Dept. of Radiology (영상의학)
Dept. of Biochemistry (생화학)
Dept. of Pathology (병리학)
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Internal Medicine (내과학)
Dept. of Plastic Surgery (성형외과학)
Institute for Medical Science (의과학연구소)
- Journal Title
- Rheumatology International
- Issued Date
- 2012
- Volume
- 32
- Issue
- 2
- Keyword
- Cry; Arthritis; Melatonin; Circadian rhythm
- Abstract
- Very recently, the circadian rhythm was proved to play an important role in the pathogenesis of arthritis. The role of melatonin in the development and progress of rheumatoid arthritis has been implicated for decades. This study was aimed to investigate the effect of melatonin on the expression of circadian clock genes in mouse anti-type II collagen antibody-induced arthritis (CIA). Mice were divided into 3 groups: control, CIA, and CIA + melatonin treatment (MLT). Both mRNA and protein levels of circadian clock gene Cryptochrome1 (Cry1) were markedly decreased in CIA + MEL group compared with those in control and CIA groups. MLT increased paw thickness. Histologic and X-ray assessment also revealed increased infiltration of inflammatory cells, synovial hyperplasia, and the destruction of articular cartilage and bone by MLT. The concentrations of anti-type II collagen antibody in CIA + MEL group mice were significantly higher than those in control and CIA groups (P<0.05). Serum concentrations of TNF-α (P<0.005) and IL-6 (P<0.05) in CIA + MLT group were also increased. Taken together, these results implicate that clock gene Cry1 may be involved in the aggravation of MLT-mediated arthritis in mice anti-type II collagen antibody-induced arthritis.
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