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Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis

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Author(s)
Jihye BangHyuk Won ChangHae-Ra JungChul-Hyun ChoJi-An HurSang-Il LeeTae Hyun ChoiSang-Hyon KimEunyoung Ha
Keimyung Author(s)
Chang, Hyuk WonHa, Eun YoungJung, Hye RaCho, Chul HyunKim, Sang HyonChoi, Tae Hyun
Department
Dept. of Radiology (영상의학)
Dept. of Biochemistry (생화학)
Dept. of Pathology (병리학)
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Internal Medicine (내과학)
Dept. of Plastic Surgery (성형외과학)
Institute for Medical Science (의과학연구소)
Journal Title
Rheumatology International
Issued Date
2012
Volume
32
Issue
2
Keyword
CryArthritisMelatoninCircadian rhythm
Abstract
Very recently, the circadian rhythm was proved to play an important role in the pathogenesis of arthritis. The role of melatonin in the development and progress of rheumatoid arthritis has been implicated for decades. This study was aimed to investigate the effect of melatonin on the expression of circadian clock genes in mouse anti-type II collagen antibody-induced arthritis (CIA). Mice were divided into 3 groups: control, CIA, and CIA + melatonin treatment (MLT). Both mRNA and protein levels of circadian clock gene Cryptochrome1 (Cry1) were markedly decreased in CIA + MEL group compared with those in control and CIA groups. MLT increased paw thickness. Histologic and X-ray assessment also revealed increased infiltration of inflammatory cells, synovial hyperplasia, and the destruction of articular cartilage and bone by MLT. The concentrations of anti-type II collagen antibody in CIA + MEL group mice were significantly higher than those in control and CIA groups (P<0.05). Serum concentrations of TNF-α (P<0.005) and IL-6 (P<0.05) in CIA + MLT group were also increased. Taken together, these results implicate that clock gene Cry1 may be involved in the aggravation of MLT-mediated arthritis in mice anti-type II collagen antibody-induced arthritis.
Keimyung Author(s)(Kor)
장혁원
하은영
정혜라
조철현
김상현
최태현
Publisher
School of Medicine
Citation
Jihye Bang et al. (2012). Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis. Rheumatology International, 32(2), 379–385. doi: 10.1007/s00296-010-1641-9
Type
Article
ISSN
0172-8172
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00296-010-1641-9
DOI
10.1007/s00296-010-1641-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34354
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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