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Suppression of collagen-induced arthritis with histone H1

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Author(s)
N JungDS KimHY KwonY-W YiD KimAD KangCH ChoSS HongHS LeeI Bae
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Scandinavian Journal of Rheumatology
Issued Date
2000
Volume
29
Issue
4
Keyword
collagen induced arthritishistone H1IL-10
Abstract
Besides roles in nucleus mediating the condensation of DNA into chromatin, the involvement of histones in autoimmune diseases, hormone regulation, and killing leukemia cells has been reported. In order to investigate the functions of histones on an autoimmune disease, histone H1 was injected into collagen-induced arthritis (CIA) mice. A dramatic suppression of CIA by histone H1 was observed at a dose of 1 mg/kg bodyweight of mouse. In addition, the increased level of anti-in¯ammatory cytokine IL-10 was detected in cultured splenocytes from the mouse treated with histone H1. These ®ndings suggest that histone H1 suppresses the collagen-induced arthritis, possibly by increasing the level of IL-10 production.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
N Jung et al. (2000). Suppression of collagen-induced arthritis with histone H1. Scandinavian Journal of Rheumatology, 29(4), 222–225. doi: 10.1080/030097400750041352
Type
Article
ISSN
0300-9742
Source
https://www.tandfonline.com/doi/abs/10.1080/030097400750041352
DOI
10.1080/030097400750041352
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34361
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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