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Fraction of immature granulocytes reflects severity but not mortality in sepsis

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Author(s)
SANG OOK HASANG HYUK PARKSO HEE PARKJAE SEOK PARKJIN WON HUHCHAE-MAN LIMYOUNSUCK KOHSANG-BUM HONGSEONGSOO JANG
Keimyung Author(s)
Park, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Scandinavian Journal of Clinical & Laboratory Investigation
Issued Date
2015
Volume
75
Issue
1
Keyword
AnalyzerbiomarkerC-reactive proteinDIClactateprocalcitonin
Abstract
Objective. In order to validate immature granulocytes as a universal biomarker, we have compared the clinical relevance of the proportion of immature granulocytes (IG%), measured using Sysmex XE-2100, with other biomarkers (white blood cell, C-reactive protein, lactate and procalcitonin). Methods. This single center, retrospective study included 184 patients with sepsis admitted to an emergency department. Patients were classified into two groups: Uncomplicated sepsis and complicated sepsis (severe sepsis and septic shock). IG% and other biomarkers were evaluated and compared for predicting sepsis severity, overt disseminated intravascular coagulation (DIC) and 28 day mortality. Results. In multivariate analysis, only IG% (odd ratio [OR] 2.530, p = 0.004) and lactate (OR 4.500, p < 0.001) could discriminate between complicated and uncomplicated sepsis. The optimal cut-off value for IG% and lactate was 0.5% and 2.0 mmol/L, respectively. In subgroup analyses of complicated sepsis, IG% was related to overt DIC. However, no single biomarker could predict 28-day mortality. Conclusions. Given that IG% reflected sepsis severity and overt DIC without additional cost, IG% could be a useful biomarker in patients with sepsis. However, there is a limitation for using it as a novel biomarker in sepsis due to the disability of prediction for 28-day mortality.
Keimyung Author(s)(Kor)
박재석
Publisher
School of Medicine
Citation
SANG OOK HA et al. (2015). Fraction of immature granulocytes reflects severity but not mortality in sepsis. Scandinavian Journal of Clinical & Laboratory Investigation, 75(1), 36–43. doi: 10.3109/00365513.2014.965736
Type
Article
ISSN
0036-5513
Source
https://www.tandfonline.com/doi/full/10.3109/00365513.2014.965736
DOI
10.3109/00365513.2014.965736
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34363
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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