계명대학교 의학도서관 Repository

Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial

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Author(s)
KOREAN TOPIRAMATE STUDY GROUP
Keimyung Author(s)
Yi, Sang Do
Department
Dept. of Neurology (신경과학)
Journal Title
Seizure
Issued Date
2002
Volume
11
Issue
4
Keyword
topiramateslow titrationefficacysafety
Abstract
Purpose: A multicentre open clinical trial was conducted to evaluate the clinical usefulness of a slower titration of topiramate (TPM) to 300 mg /day as adjunctive therapy for medically intractable partial epilepsies.
Methods: Ninteen centres participated in the trial. Study patients had to have had two or more seizures per 4 weeks whilst taking maximum tolerated doses of one but not more than two anti-epileptic drugs. The starting dose of TPM was 25 mg /day and the dose was increased weekly by 25 mg /day until 100 mg /day was reached. Thereafter TPM was increased by 50 mg /day weekly up to the target dose of 300 mg /day, which was followed by an 8 week maintence phase. Seizure outcomes were measured by intention-to-treat analysis (ITTA)
Results: Two hundred and thirteen patients entered the study. Median seizure frequency reduction rate was 44.8%, responder rate was 47.6%, and seizure free rate was 9.0%. These results were comparable to that of TPM 600 mg /day in our previous controlled trial. In subgroup analysis, seizure free rate was higher in those patients with a lower baseline seizure frequency rate. Seventeen patients (8.0%) were prematurely withdrawn from the study due to adverse events (AE) or lack of effect. One or more AEs were reported in 22% of patients, with dizziness being the most frequent AE. Other AEs occurred in less than 5% of patients.
Conclusion: TPM 300 mg /day was effective and in conjunction with a slower dose-titration, markedly reduced the incidence of AEs, compared with previous study.
Keimyung Author(s)(Kor)
이상도
Publisher
School of Medicine
Citation
KOREAN TOPIRAMATE STUDY GROUP. (2002). Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial. Seizure, 11(4), 255–260. doi: 10.1053/seiz.2001.0605
Type
Article
ISSN
1059-1311
DOI
10.1053/seiz.2001.0605
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34374
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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