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Predictors of quality of life and their interrelations in Korean people with epilepsy: A MEPSY study

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Author(s)
Se-Jin LeeJi-Eun KimJong-Geun SeoYong Won ChoJang-Joon LeeHye-Jin MoonSung-Pa Park
Keimyung Author(s)
Cho, Yong WonMoon, Hye Jin
Department
Dept. of Neurology (신경과학)
Journal Title
Seizure
Issued Date
2014
Volume
23
Issue
9
Keyword
EpilepsyPredictorQuality of lifeDepressionAdverse effectSeizure control
Abstract
Purpose: People with epilepsy (PWE) are more likely to have impaired quality of life (QOL) than the general population. We studied predictors of QOL and their interrelations in Korean PWE.
Methods: Subjects who consecutively visited outpatient clinics in four tertiary hospitals and one secondary care hospital were enrolled. These subjects completed the Korean version of the Neurological Disorders Depression Inventory for Epilepsy (K-NDDI-E), the Generalized Anxiety Disorder-7 (GAD-7), the Quality of Life in Epilepsy-10 (QOLIE-10), and the Korean version of Liverpool Adverse Event Profile (K-LAEP). We evaluated the predictors of QOL by multiple regression analyses and verified the interrelations between the variables using a structural equation model.
Results: A total of 702 PWE were eligible for the study. The strongest predictor of the overall QOLIE-10 score was the K-LAEP score (β=-0.375, p<0.001), followed by the K-NDDI-E score (β=-0.316, p<0.001), seizure control (β=-0.152, p<0.001), household income (β=-0.375, p<0.001), and GAD-7 score (β=-0.119, p=0.005). These variables explained 68.7% of the variance in the overall QOLIE-31 score. Depression and seizure control had a bidirectional relationship and exerted direct effects on QOL. These factors also exerted indirect effects on QOL by provoking adverse effects of AEDs. Anxiety did not have a direct effect on QOL; it had only indirect effect through the adverse effects of AEDs.
Conclusion: Depression, anxiety, seizure control, and adverse effects of AEDs have complex interrelations that determine the QOL of PWE.
Keimyung Author(s)(Kor)
조용원
문혜진
Publisher
School of Medicine
Citation
Se-Jin Lee et al. (2014). Predictors of quality of life and their interrelations in Korean people with epilepsy: A MEPSY study. Seizure, 23(9), 762–768. doi: 10.1016/j.seizure.2014.06.007
Type
Article
ISSN
1059-1311
DOI
10.1016/j.seizure.2014.06.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34375
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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