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The effect of levetiracetam monotherapy on subjective sleep quality and objective sleep parameters in patients with epilepsy: Compared with the effect of carbamazepine-CR monotherapy

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Author(s)
Yong Won ChoDo Hyung KimGholam K. Motamedi
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Seizure
Issued Date
2011
Volume
20
Issue
4
Keyword
Partial epilepsySleepPolysomnographyLevetiracetamCarbamazepine
Abstract
Purpose: There is relatively little known about the effects of new antiepileptic drugs (AEDs) on sleep. This study was done to evaluate the effect of levetiracetam (LEV) on subjective sleep quality and sleep architecture in patients with epilepsy, and the results were compared with the effects of carbamazepine-CR (CBZ-CR).
Methods: This is a longitudinal randomized controlled trial using two different treatments, LEV (1000 mg/day) or CBZ-CR (400 mg/day). Thirty-one subjects (16 LEV and 15 CBZ-CR) had partial epilepsy and were tested with an overnight polysomnography (PSG) with full 10–20 electrodes. Sleep questionnaires and National Hospital Seizure severity Scale (NHS3) were evaluated. PSG and the questionnaires were repeated after 4–6 weeks of treatment.
Results: In the LEV group, when treatment PSG findings were compared with baseline, there was a significant increase in sleep efficiency (p = 0.039) but no changes in subjective sleep parameters. In the CBZ-CR group, there was a significant increase in the percentage of slow wave sleep (p = 0.038) while other sleep parameters were not significantly changed after treatment. There were no significant differences in effects on sleep between the LEV and CBZ-CR groups.
Conclusion: LEV may increase sleep efficiency without major effects on sleep structure with an overall effect on sleep parameters comparable to CBZ-CR.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Yong Won Cho et al. (2011). The effect of levetiracetam monotherapy on subjective sleep quality and objective sleep parameters in patients with epilepsy: Compared with the effect of carbamazepine-CR monotherapy. Seizure, 20(4), 336–339. doi: 10.1016/j.seizure.2011.01.006
Type
Article
ISSN
1059-1311
DOI
10.1016/j.seizure.2011.01.006
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34377
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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