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Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: comparison with chronic osteoarthritis

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Author(s)
Yong Won ChoGeon Youb NaJeong Geun LimSang-Hyon KimHye Soon KimChristopher J. EarleyRichard P. Allen
Keimyung Author(s)
Cho, Yong WonLim, Jeong GeunKim, Sang HyonKim, Hye Soon
Department
Dept. of Neurology (신경과학)
Dept. of Internal Medicine (내과학)
Journal Title
Sleep Medicine
Issued Date
2013
Volume
14
Issue
12
Keyword
Restless legs syndromeWillis Ekbom diseaseDiabetic peripheral neuropathyOsteoarthritisSleep disorderDiabetes mellitus
Abstract
Background: The prevalence of restless legs syndrome (RLS) in patients with peripheral neuropathy has been reported to be higher than that of the general population in some studies, which suggests an association between neuropathy and RLS, but not all studies show increased RLS with neuropathy. These differences may reflect adequacy of the diagnosis, effects of chronic pain complicating the diagnosis, or population differences. Moreover, if there is increased risk for RLS with neuropathy, it may reflect consequences of the chronic pain rather than other aspects of diabetes mellitus (DM). Therefore, we investigated the effects of diagnosis rigor on the estimated prevalence of RLS in patients with diabetic peripheral neuropathy (DPN) and those with chronic leg pain from osteoarthritis (OA), and then we compared the RLS prevalence in these two populations with each other and with population prevalence for Korea.
Methods: Our study is a prospective case-control study of 199 patients with DPN and 220 patients with OA. After evaluating the presence of RLS in these subjects using the diagnostic criteria of the International RLS Study Group, we confirmed the diagnosis of RLS through face-to-face interviews using the 18-item Hopkins Diagnostic Questionnaire, which removes RLS mimics; and through independent examinations by two neurologists.
Results: Of the 199 subjects with DPN, 44 (22%) appeared to have RLS from their answers on the 4-item RLS diagnostic questionnaire compared to 8 (3.6%) of 220 subjects with OA. However, the prevalence of RLS in the DPN group dropped to 16 (8%) subjects but stayed at 8 (3.6%) OA subjects when using the Hopkins Telephone Diagnostic Interview (HTDI) adapted for clinical interview. The RLS prevalence determined by HTDI remained significantly higher (P = .042) in the DPN group compared to the OA group and was twice that reported for the general Korean population (8% vs 3.9%). Among subjects with DPN, those with RLS were older (68.06 ± 8.43 years vs 62.46±11.05 years; P=.049) and had higher pain scores (visual analog scale [VAS], 4.69±2.52 vs 2.72±2.12; P=.002). The quality of sleep (MOS [Medical Outcomes Study] sleep scale) and health-related quality of life (QoL) (total score on the 36-Item Short-Form Health Survey [SF-36]) showed no significant difference between the two groups.
Conclusions: The prevalence of RLS in patients with DPN cannot be accurately assessed with only the four diagnostic criteria interview, but the prevalence was higher than expected for Koreans from the general population prevalence and also was higher than occurred with OA patients with chronic leg pains when accurately assessed with a structured interview. Chronic leg pain from OA does not significantly complicate RLS diagnosis, and chronic pain itself does not explain the increased RLS prevalence in diabetic neuropathy.
Keimyung Author(s)(Kor)
조용원
임정근
김상현
김혜순
Publisher
School of Medicine
Citation
Yong Won Cho et al. (2013). Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: comparison with chronic osteoarthritis. Sleep Medicine, 14(12), 1387–1392. doi: 10.1016/j.sleep.2013.09.013
Type
Article
ISSN
1389-9457
Source
https://www.sciencedirect.com/science/article/pii/S1389945713011532?via%3Dihub
DOI
10.1016/j.sleep.2013.09.013
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34405
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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