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Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging

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Author(s)
Jeonghun KuYong Won ChoYeong Seon LeeHye-Jin MoonHyukWon ChangChristopher J. EarleyRichard P. Allen
Keimyung Author(s)
Ku, Jeong HunCho, Yong WonMoon, Hye JinChang, Hyuk Won
Department
Dept. of Biomedical Engineering (의용공학과)
Dept. of Neurology (신경과학)
Dept. of Radiology (영상의학)
Journal Title
Sleep Medicine
Issued Date
2014
Volume
15
Issue
3
Keyword
Restless legs syndrome (RLS)Resting fMRIConnectivityThalamusCentral painMRI
Abstract
Background: Restless legs syndrome (RLS) is a primary sensory disorder with a secondary motor component (e.g., urge to move), and the thalamus is known to play a central role in RLS. The purpose of our study was to explore the intrinsic changes in the thalamocortical circuit in RLS patients using a resting-state functional magnetic resonance imaging (fMRI) paradigm.
Methods: Resting-state fMRIs were obtained in the morning from 25 idiopathic RLS patients who were not using RLS medications and 25 controls. Resting-state connectivity was analyzed by a seed-based method using Analysis of Functional NeuroImages (AFNI) software with the bilateral thalami (ventroposterolateral nucleus [VPLN]). The connectivity characteristics of RLS patients were compared to those of the controls.
Results: We found that RLS patients showed reduced thalamic connectivity with the right parahippocampal gyrus, right precuneus, right precentral gyrus, and bilateral lingual gyri; however, the right superior temporal gyrus, bilateral middle temporal gyrus, and right medial frontal gyrus showed enhanced connectivity with the thalamus. RLS severity was negatively correlated with connectivity between the thalamus and right parahippocampal gyrus (r=-0.414; P=.040).
Conclusions: Our results suggest that the characteristics of the connectivity changes may reflect the pathways involved in producing RLS symptoms and indicate that RLS patients may have deficits in controlling and managing sensory information, which supports the act of viewing RLS as a disorder disrupting somatosensory processing.
Keimyung Author(s)(Kor)
구정훈
조용원
문혜진
장혁원
Publisher
School of Medicine
Citation
Jeonghun Ku et al. (2014). Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging. Sleep Medicine, 15(3), 289–294. doi: 10.1016/j.sleep.2013.09.030
Type
Article
ISSN
1389-9457
Source
https://www.sciencedirect.com/science/article/pii/S1389945714000306?via%3Dihub
DOI
10.1016/j.sleep.2013.09.030
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34407
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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