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Baicalein and 12/15-Lipoxygenase in the Ischemic Brain

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Author(s)
Klaus van LeyenHahn Young KimSeong-Ryong LeeGuang JinKen AraiEng H. Lo
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Journal Title
Stroke
Issued Date
2006
Volume
37
Issue
12
Keyword
antioxidantbaicaleinischemialipoxygenase neuron
Abstract
Background and Purpose: The natural product baicalein is a specific inhibitor of 12/15-lipoxygenase, but it also has antioxidant properties. The current study was designed to test if the neuroprotective properties of baicalein are related to its lipoxygenase inhibition.
Methods: The presence of 12/15-lipoxygenase in the ischemic mouse brain was demonstrated by immunohistochemistry. A mouse model of transient middle cerebral artery occlusion was used to study lipoxygenase-dependent protection of the ischemic brain by baicalein. Rat primary neurons were subjected to oxidative stress in the presence or absence of baicalein.
Results: In a mouse model of transient middle cerebral artery occlusion, 12/15-lipoxygenase is increased in the peri-infarct area surrounding the primary infarction, predominantly in neurons. Oxidative toxicity in primary rat neurons is reduced by baicalein. C57Bl6J mice are protected against transient focal ischemia by intraperitoneal injection of baicalein, and a similar degree of protection is seen in 12/15-lipoxygenase knockout mice compared with wild-type mice. In contrast, the 12/15-LOX knockout mice are not further protected by baicalein.
Conclusion: Baicalein protects against ischemia/reperfusion injury by inhibiting the 12/15-lipoxygenase pathway to neuronal cell death.
Keimyung Author(s)(Kor)
이성용
Publisher
School of Medicine
Citation
Klaus van Leyen et al. (2006). Baicalein and 12/15-Lipoxygenase in the Ischemic Brain. Stroke, 37(12), 3014–3018. doi: 10.1161/01.STR.0000249004.25444.a5
Type
Article
ISSN
0039-2499
DOI
10.1161/01.STR.0000249004.25444.a5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34416
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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