계명대학교 의학도서관 Repository

The dosing frequency of sustained-release opioids and the prevalence of end-of-dose failure in cancer pain control: a Korean multicenter study

Metadata Downloads
Author(s)
Do-Yeun KimHong-Suk SongJin-Seok AhnBaek-Yeol RyooDong-Bok ShinChang-Yeol YimSi-Young Kim
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Supportive Care in Cancer
Issued Date
2011
Volume
19
Issue
2
Keyword
Opioid analgesicsCancerPain
Abstract
Background End-of-dose failure is commonly observed as
therapeutic levels of sustained-release opioids fall. However,
little is known about using these medications for cancer pain
control. To determine the dosing frequency of sustainedrelease
opioids (morphine, oxycodone, and transdermal
fentanyl) and the prevalence of end-of-dose failure in clinical
practice, a patient-reported survey was performed.
Methods A multicenter survey was conducted in 56
hospitals in Korea between June and November 2008.
Results The study enrolled 1,097 cancer outpatients who
were prescribed oral sustained-release opioids (morphine or
oxycodone) or transdermal fentanyl. Of the oral sustainedrelease
opioid patients, 67.0% took oral sustained-release oral
opioids twice daily, while 26.2% took them more than twice
daily. Of the transdermal fentanyl patients, 88.8% wore the
patch for 72 h. Of the enrolled patients, 48.3% experienced
worsening pain just before the next sustained-release opioid
dose, and 36.8% of these patients took medication earlier than
the prescribed dosing schedule. Patients felt that oral
sustained-release opioids gave adequate pain control lasting
an average of 9.6 h, versus an average of 62.9 h for
transdermal fentanyl.
Conclusion This survey demonstrated that sustained-release
opioids are used by patients in a manner that is inconsistent
with standard recommendations. End-of-dose failure is
suggested to explain increased dosing frequency, and patients
reported that adequate pain relief lasted for less time than was
stated in the manufacturers’ prescription recommendation.
Keywords Opioid analgesics . Cancer . Pain
Keimyung Author(s)(Kor)
송홍석
Publisher
School of Medicine
Citation
Do-Yeun Kim et al. (2011). The dosing frequency of sustained-release opioids and the prevalence of end-of-dose failure in cancer pain control: a Korean multicenter study. Supportive Care in Cancer, 19(2), 297–301. doi: 10.1007/s00520-010-0825-x
Type
Article
ISSN
0941-4355
Source
https://link.springer.com/article/10.1007%2Fs00520-010-0825-x
DOI
10.1007/s00520-010-0825-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34430
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.